ABSTRACT
Statement of the Problem: The expression of minichromosome maintenance-3 [MCM3] proteins and their diagnostic value in oral mucosal dysplasia and squamous cell carcinoma [SCC] is not well known.
Purpose: This study was conducted to evaluate the usefulness of minichromosome maintenance 3 [MCM3] as a biomarker for diagnosis of oral premalignant lesions and SCC.
Materials and Method: In this study, 31 oral SCC, 20 dysplastic epithelium and 20 controls were selected and immunohistochemical staining was done for MCM3. ANOVA, Tukey HSD, Mann-Whitney and Kruskal-Wallis tests were used to compare the groups and the correlation between different grades
Results: There was increasing trend of MCM3 from control to dysplastic epithelium and from dysplastic epithelium to SCC both in suprabasal layers and in total epithelial layers. MCM3 expression was elevated with increasing the grade of dysplasia, but there was no statistically significant difference [p= 0.93]. The expression was also increased in high grades of SCC compared to lower grades
Conclusion: MCM3 can be used as a useful biomarker in the diagnosis of premalignant lesions and oral SCC
ABSTRACT
Actinomycosis is an anaerobic infection that involves the craniofacial region and its colonization has rarely been reported in the developmental odontogenic cysts. In the present report, a case of odontogenic keratocyst [which is now called keratocystic odontogenic tumor] with the colonization of actinomyces is introduced and its significance is discussed
ABSTRACT
Oral and maxillofacial lesions vary regarding their clinical presentation in different populations. Until now, oral and maxillofacial lesions in Iranian children and adolescents have not been studied. The aim of this study was to determine the type and distribution of biopsied oral lesions among children and adolescents in Southern Iran. All the patients referred to the pathology department of Shiraz Faculty of Dentistry from 1991-2009 were enrolled in this retrospective, case-series study. The information regarding the patients' age, gender as well as the histopathologic type and anatomic location of the biopsied oral lesions in patients under 18 years was collected from patients' medical documents and were analyzed by SPSS version 11. Out of 2984 patients, 576 [19.3 %] cases were children and adolescents under 18 years. The most prevalent category was soft tissue lesions [45.5 %]. The most common lesion was peripheral giant cell granuloma [15.6%] followed by dentigerous cyst [14.2%] and pyogenic granuloma [11.3%]. Gingiva was the most common affected site. Male to female ratio was 1.2. Our results revealed that near 20% of orofacial lesions occur in children and adolescents with rather equal male to female ratio. The majority of lesions were soft tissue diseases with a reactive nature. Unlike other studies we had higher rates of soft tissue lesions. These data can help dentists and surgeons for more accurate management of their patients