ABSTRACT
Background: Diabetes mellitus [DM] is one of the most common metabolic diseases in humans, affecting 100 million people around the world
Objective: Investigating the effects of Citrullus colocynthis pulp on oxidant and antioxidant factors of testes and epididymis in streptozotocin-induced diabetic male rats
Materials and Methods: Thirty-two male rats were divided into four groups eight each: 1] N [normal] group, 2] N+C group, 3] D [diabetic] group and 4] D+C group. Groups N and D received normal saline 2 ml orally for two weeks and groups N+C and D+C received 10 mg/kg.bw Citrullus colocynthis pulp orally for two weeks. Diabetes was induced by single intraperitoneal injection of streptozotocin [STZ] at 65 mg/kg
Results: D group had a significant increase in H2O2 [Hydrogen peroxide] and MDA [malondialdehyde] concentrations, and CAT [catalase] activity, and also a significant decrease in Peroxidase [POD] activity compared to N group. D+C group had a significant decrease in H2O2 and MDA concentrations and, CAT activity and significant increase in POD activity compared to D group
Conclusion: Citrullus colocynthis pulp in two weeks had beneficial effects on oxidants and antioxidants changes in reproductive system in streptozotocin-induced diabetic rats