ABSTRACT
Background: testicular damage due to spermatic cord torsion may lead to infertility. It is probably because of changes in oxidative stress factors such as malondialdehyde
Objective: to investigate the protective effect of melatonin [MLT], as an antioxidant, on testicular damage induced by acute unilateral spermatic cord torsion and detorsion [T/D] in rats
Materials and Methods: in this experimental study, 48 adult male Wistar rats were randomly divided into three groups [8 rats/group]: sham group underwent right scrotal surgery only., the T/D group underwent right testicular torsion [for 1 hr] and detorsion, and the melatonin group underwent right testicular torsion, received 25 microg/kg melatonin intraperitoneally immediately after surgery of T/D. Then the histological parameters and malondialdehyde [MDA] changes were evaluated
Results: torsion and detorsion decreased the diameter of the tubules significantly compared to controls [p=0.003]. Melatonin could increase the diameter, but it was not significant [p=0.26]. The heights of the epithelium were constant in sham, T/D, and melatonin groups without any significant difference between groups [p=0.98]. Based on Johnsen's score, spermatogenesis was normal in the sham group. The torsion significantly injured all lineage cells [p<0.001]. There was no any spermatid or sperm in the seminiferous tubules. Melatonin improved the spermatogenesis significantly [p=0.02], but could not improve MDA level significantly [p=0.99]
Conclusion: severe degenerative changes of testis were induced by acute unilateral spermatic cord torsion and detorsion in rats, but it had no effect on MDA level
ABSTRACT
Background: Aphallia or penile agenesis is a rare malformation accompanying with no phallus. This anomaly is extremely rare with abnormality of urogenital system and psychological consequences. Its outbreak is estimated 1 out of 10-30 million births
Case: Reviewing 3 cases of male external genitalia agenesis, which associated with multiple anomalies of musculoskeletal, cardiovascular and genitourinary system
Conclusion: Aphallia has psychosocial consequences and a guarded prognosis. This study showed that if the kidney failure is due to its obstruction, these patients will be born in more favorable conditions and the future treatment measures will be directed to keep the external genitalia [male] through timely diagnosis and prenatal surgery and timely bladder drainage