ABSTRACT
Abstract Woolly hair nevus is a rare condition characterized by a structural anomaly of the hair, restricted to certain areas of the scalp. The hair becomes coiled and slightly hypopigmented. The term woolly hair refers to changes that affect all the scalp and has a hereditary character. We present a case of woolly hair nevus, that developed at the age of 2 years, associated with dental diastema and verrucous epidermal nevus.
Subject(s)
Humans , Male , Child , Skin Neoplasms/pathology , Diastema/pathology , Nevus, Sebaceous of Jadassohn/pathology , Hair Diseases/pathology , Nevus/pathologyABSTRACT
Abstract Childhood linear immunoglobulin A dermatosis is a rare autoimmune vesiculobullous disease. It results in linear deposition of autoantibodies (immunoglobulin A) against antigens in the basal membrane zone, leading to subepidermal cleavage. Additional depositions of immunoglobulin G and complement-3 might occur. It is still debated whether concomitant findings of immunoglobulins A and G should be considered a subtype of this dermatosis or a new entity. Further studies are needed to recognize this clinical variant.
Subject(s)
Humans , Male , Child , Skin/pathology , Linear IgA Bullous Dermatosis/pathology , Basement Membrane/pathology , Biopsy , Skin Diseases, Vesiculobullous/pathology , Fluorescent Antibody Technique, Direct , Erythema/pathologyABSTRACT
AbstractTaxanes are drugs used to treat many types of cancer, including breast and lung cancer. The most common side effects of these drugs are neutropenia and mucositis. Signs of skin toxicity are observed in about 65% of cases and include alopecia, hypersensitivity reactions, persistent supravenous erythematous eruption, nail changes, scleroderma reactions and others. We report two cases of skin reaction to docetaxel and warn that it is not necessary to interrupt the treatment in these cases.
Subject(s)
Aged , Female , Humans , Antineoplastic Agents/adverse effects , Drug Eruptions/etiology , Erythema/chemically induced , Taxoids/adverse effects , Drug Eruptions/pathology , Erythema/pathology , Skin/pathologyABSTRACT
O nevo sebáceo de Jadassonh é um nevo epidérmico composto por glândulas sebáceas de coloração rosa ou amarelada, que pode apresentar o desenvolvimento de várias neoplasias benignas e malignas. É uma das malformações anexais que ocorre com maior frequência nas crianças1,2. Clinicamente aparece como uma placa bem definida de alopecia no couro cabeludo, face ou colo. Está presente desde o nascimento ou pode surgir alguns anos mais tarde1. Apresentamos o caso de um nevo sebáceo de Jadassohn no couro cabeludo a partir do qual um carcinoma basocelular se desenvolveu e foi diagnosticado com o auxílio da dermatoscopia.
ABSTRACT
Cowden's disease or multiple hamartoma syndrome is an autosomal dominant inherited disease and the main dermatological features are facial trichilemmomas (hamartomas of the follicular infundibula), oral fibroma and benign acral keratoses. The importance of this disease lays in the increased susceptibility to malignization of some lesions, especially breast, thyroid and genitourinary tract. Despite its varied phenotypic expression, this disease is generally unknown. Consequently, many cases are undiagnosed or diagnosis comes at a late stage, which reinforces the importance of an early investigation of the disease so the patient may have periodic check-ups to discover and treat malignancies.
A doença de Cowden ou síndrome dos hamartomas múltiplos é de transmissão autossômica dominante cuja tríade dermatológica compõem-se de triquilemomas faciais múltiplos (hamartomas do infundíbulo folicular), fibromas orais e queratoses acrais benignas. A importância desta doença está no aumento da susceptibilidade a malignização de algumas lesões, especialmente de mama, tireóide e trato genito-urinário. Apesar da expressão fenotípica variada, esta doença é geralmente desconhecida. Consequentemente, muitos casos não são diagnosticados ou o diagnóstico vem tardiamente, o que ressalta a importância do diagnóstico precoce da doença para que o paciente possa ser monitorado periodicamente para diagnóstico e tratamento precoce de doenças malignas.