ABSTRACT
Abstract Sjogren's syndrome (SS) is an autoimmune disease characterized by lymphocytic infiltration of the exocrine glands and other organs, associated with sicca syndrome but also with systemic involvement with varying degrees of severity. Despite their importance, some systemic manifestations, mainly liver, gastrointestinal, and pancreatic are not routinely evaluated. To address these manifestations, the Sjögren's Syndrome Committee of the Brazilian Society of Rheumatology conducted a broad systematic review of the literature on studies investigating prevalence and diagnosis of these symptoms in Sjogren´s patients and made recommendations based on the findings. Agreement between the experts was achieved using the Delphi method. This is the second part of this guideline, providing 6 recommendations for liver, gastrointestinal, and pancreatic care of SS patients.
ABSTRACT
Abstract Sjogren's Syndrome (SS) is an autoimmune disease characterized by lymphocytic infiltration of the exocrine glands and other organs, associated with sicca syndrome but also with systemic involvement with varying degrees of severity. Despite their importance, these systemic manifestations are not routinely evaluated and there is no homogenous approach to their diagnosis or evaluation. To close this gap, a panel of experts from the Brazilian Society of Rheumatology conducted a systematic review and meta-analysis on the identification of epidemiologic and clinical features of these manifestations and made recommendations based on the findings. Agreement between the experts was achieved using the Delphi method. The first part of this guideline summarizes the most important topics, and 11 recommendations are provided for the articular, pulmonary, and renal care of SS patients.
ABSTRACT
Abstract Sjogren's syndrome (SS) is an autoimmune disease characterized by lymphocytic infiltration of the exocrine glands and other organs. Women with SS often experience gynecological symptoms due to the disease and need extra care regarding their sexual activity, reproductive health and during pregnancy, conditions that are not properly conducted in the clinical practice. To cover this gap, a panel of experts from the Brazilian Society of Rheumatology conducted a systematic review and meta-analysis on the identification of symptoms, diagnosis, monitoring, prognosis, and treatment of these manifestations. A Focus Group meeting was held and included experts in the field and methodologists, based on a previously developed script, with themes related to the objective of the study. The most important topics were summarized and 11 recommendations were provided.
ABSTRACT
Abstract Background: Primary Sjögren's syndrome (pSS) is a systemic immune-mediated disease whose main characteristic is exocrine gland inflammation and, subsequent reduction in tear and saliva production. A delayed diagnosis is common due to the nonspecific clinical manifestations of disease. The aim of the present study was to develop recommendations for the diagnosis of glandular manifestations of pSS based on evidence and expert opinion. Main body of the abstract: We conducted a systematic literature review to retrieve the best evidence available on the accuracy of diagnostic tests for pSS. We also held two in-person meetings with experts (rheumatologists, pathologists, ophthalmologists and dentists) to establish their level of agreement using the Delphi method. Ultimately, we generated 18 recommendations that aim to facilitate the diagnosis of the glandular manifestations of pSS. Conclusion: The diagnosis of glandular manifestations of pSS is complex and multidisciplinary. It requires specific knowledge in the field of ophthalmology, immunology, pathology and imaging, making it compulsory for the rheumatologist to work with professionals from these different areas in order to improve accuracy and early diagnosis. Glandular dysfunction tests, ANA, RF, Anti-Ro, protein electrophoresis, urinalysis, blood count, C-Reactive protein, complement, testing for syphilis and viruses (HCV, HIV) and SGUS should be investigated when dryness or systemic manifestation are present. Minor salivary gland biopsy is recommended for all anti-Ro negative or incomplete criteria cases.
Subject(s)
Humans , Sjogren's Syndrome/diagnosis , Rheumatology , Salivary Gland Diseases/diagnosis , Salivary Glands/diagnostic imaging , Salivation , Societies, Medical , Xerostomia/diagnosis , Xerostomia/etiology , Brazil , Magnetic Resonance Imaging , Dry Eye Syndromes/diagnosis , Dry Eye Syndromes/etiology , Sjogren's Syndrome/complications , Delphi Technique , Ultrasonography , Consensus , Dentists , Positron-Emission Tomography , Ophthalmologists , Pathologists , RheumatologistsABSTRACT
Os autores fazem um estudo retrospectivo sobre a incidência de infecçåoem 250 pacientes portadores de lúpus eritematoso sistêmico. Foi encontradauma incidência de 44,8//de infecçåo em diversas fases de evoluçåo da doença. Pneumonias bacterianas agudas ocorreram em 42,8//dos casos; infecçÆes cutâneas extensas em 18,7//; tuberculose em 17,8//; septicemias em 14,2//; infecçÆes do sistema nervoso em 5,3//; endocardite bacteriana, meningite por Cryptococcus neoformans e osteomielite em 2,6//dos casos cada. Ocorreram ainda dois casos de escabiose norueguesa, e um caso cada de pericardite purulenta, artrite séptica, candidíase disseminada e hiperinfestaçåo por Strongyloides stercoralis. 65,1//dos casos apresentavam nefropatia no momento da infecçåo, enquanto apenas 34,8//nåo apresentavam doença renal. Dos óbitos ocorridos, 27//foram devidos à infecçåo. Chamamos assim a atençåo para a importância de complicaçÆes infecciosas nos pacientes portadores de lúpus, principalmente nas fases de atividade da doença
Subject(s)
Humans , Male , Female , Child , Adolescent , Adult , Middle Aged , Lupus Erythematosus, Systemic/complications , Lupus Erythematosus, Systemic/epidemiology , Lupus Erythematosus, Systemic/etiology , Multicenter Studies as TopicABSTRACT
Os autores descrevem três doentes com poliarterite nodosa cutânea, sendo que dois apresentavam nódulos subcutâneos e um ulceraçöes cutâneas, acompanhadas de febre, leucocitose e hemossedimentaçäo elevada. Em dois casos, poliartrites acompanharam o quadro cutâneo