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Rev. bras. reumatol ; 55(6): 493-500, nov.-dez. 2015. tab
Article in English | LILACS | ID: lil-770019

ABSTRACT

Resumo Objetivo: Caracterizar pacientes com artrite reumatoide (AR) quanto à presença de fatores de risco para doenças cardiovasculares. Material e métodos: Estudo transversal descritivo com 71 pacientes diagnosticados com AR definida. Foram usados os instrumentos: DAS-28, HAQ e SF-36 e determinados os parâmetros: velocidade de hemossedimentação, glicemia capilar, colesterol total (CT) e suas frações, hormônios tiroidianos, anticorpos antinúcleo (ANA), fator reumatoide (FR) e anticorpos contra proteínas citrulinadas (ACPAs). Os pacientes foram classificados em grupos HAQ ≤ 1 (disfunção leve) e HAQ > 1 (disfunção moderada e grave) e, segundo os escores do HAQ, em grupo tratado com corticosteroides (CE) e sem CE. Resultados: Proporção de nove homens para 62 mulheres com idade e tempo médio de doença de 53,45 (± 10,7) e 9,9 (± 8,6), respectivamente. O FR foi positivo em 52 (76%), os ACPAs em 54 (76,1%) e o ANA em 12 (16,9%). Trinta e seis pacientes (50,7%) apresentaram hipertensão arterial sistêmica, nove (12,68%) diabetes mellitus, 16 (22,5%) hipotireoidismo, 33 (46,5%) dislipidemia e oito (11,27%) tabagismo. O grupo HAQ > 1 (26) apresentou resultados de CT > 240 (53,8%) e o grupo com HAQ ≤ 1 (45) (24,4%) (p = 0,020). Os grupos não diferiram quanto à presença de comorbidades ou tratamento farmacológico. Os níveis de triglicérides > 200 (42,4%) entre os grupos em uso de CE e sem uso (18,42%) foi significativo (p = 0,025). Conclusão: Houve associação do aumento CT e triglicerídeos com resultados de HAQ ≤ 1 e com uso de CE, o que reforça a importância do rastreamento de fatores de risco associados às doenças cardiovasculares na AR.


Abstract Objective: To identify risk factors for cardiovascular disease in patients with Rheumatoid Arthritis (RA). Material and methods: A descriptive cross-sectional study with 71 patients with established RA. The instruments used were: DAS-28, HAQ and SF-36, and the following parameters were determined: the erythrocyte sedimentation rate, capillary blood glucose; total cholesterol (TC) and its fractions, thyroid hormones, antinuclear antibodies (ANA), rheumatoid factor (RF) and antibodies against citrullinated proteins (ACPAs). Patients were classified into groups HAQ ≤ 1 (mild dysfunction) and HAQ > 1 (moderate and severe dysfunction) and, according to the HAQ scores, in groups treated with corticosteroids (CS) and without CS. Results: 9 patients were male and 62 female with mean age and duration of disease of 53.45 (±10.7) and 9.9 (±8.6), respectively. RF was positive in 52 (76%), ACPAs in 54 (76.1%) and ANA in 12 (16.9%). Thirty-six patients (50.7%) had systemic hypertension, 9 (12.68%) diabetes mellitus, 16 (22.5%) hypothyroidism, 33 (46.5%) dyslipidemia and 8 (11.27%) were smokers. The results of TC > 240 were found in 53.8% for group HAQ > 1 (26) and in 24.4% for group HAQ ≤ 1 (45) (p = 0.020). These groups did not differ as to presence of comorbidities or drug treatment. Triglyceride levels >200 for the group with CS (42.4%) versus without CS (18.42%) were significant (p = 0.025). Conclusion: An association of increased TC and triglycerides with results of HAQ ≤ 1 and with CS use was noted, reinforcing the importance of screening risk factors associated with cardiovascular disease in RA.


Subject(s)
Humans , Male , Female , Arthritis, Rheumatoid/complications , Cardiovascular Diseases/etiology , Arthritis, Rheumatoid/blood , Rheumatoid Factor/blood , Blood Glucose/analysis , Blood Sedimentation , Brazil , Cardiovascular Diseases/blood , Cholesterol/blood , Cross-Sectional Studies , Risk Factors , Anti-Citrullinated Protein Antibodies/blood , Middle Aged
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