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1.
Rev. Soc. Bras. Med. Trop ; 54: e0247-2020, 2021. tab, graf
Article in English | LILACS | ID: biblio-1155527

ABSTRACT

Abstract INTRODUCTION: This study estimated the seroprevalence and risk factors of Chagas disease (CD) in a population of the Quixeré municipality, Ceará. METHODS: We conducted serological methods to detect the Trypanosoma cruzi infection. The other variables were evaluated by a standardized questionnaire. RESULTS: The estimated prevalence of CD was 3.7%. Male sex, age >40 years, being farmers, low education level, origin from rural areas, and being born in Quixeré were significantly associated with infection. CONCLUSION: CD persists in this rural population of Northeast Brazil. Poverty, low education, and limited information regarding CD are critical issues that need to be addressed.


Subject(s)
Humans , Male , Adult , Trypanosoma cruzi , Chagas Disease/epidemiology , Rural Population , Brazil/epidemiology , Seroepidemiologic Studies , Prevalence , Risk Factors
2.
Arq. bras. cardiol ; 115(6): 1082-1091, dez. 2020. tab, graf
Article in English, Portuguese | LILACS | ID: biblio-1152955

ABSTRACT

Resumo Fundamento A doença de Chagas (DC) é considerada um problema de saúde pública na América Latina. A região nordeste, principalmente o estado do Ceará, ainda representa grande preocupação em termos de risco de transmissão da doença. Objetivo Estimar a prevalência de T. cruzi em doadores de sangue do estado do Ceará. Métodos Trata-se um de estudo retrospectivo descritivo realizado no período de 2010 a 2015, a partir de dados registrados no sistema informatizado do Centro de Hematologia e Hemoterapia do Ceará (HEMOCE). Resultados Dos 763.731 potenciais doadores de sangue, 14.159 foram considerados impedidos de fazer a doação devido à sorologia, sendo que 1.982 (0,33%) o foram devido à positividade/inconclusão para doença de Chagas. Compareceram à Hemorrede para a repetição 425 indivíduos, sendo confirmados 28,2% (120/425) como impedidos de doar devido a DC. Conclusão Não houve redução significativa das sorologias positivas/inconclusivas no período entre 2010-2015, porém foi observada redução em relação a 1996/1997 no estado. A determinação da prevalência da doença de Chagas em bancos de sangue pode ser relevante como indicador do risco de transmissão transfusional em determinada região. Novos testes sorológicos para triagem com melhor acurácia são necessários, reduzindo o descarte desnecessário de bolsas de sangue, os custos para o Sistema Único de Saúde e a insegurança para os pacientes e familiares. (Arq Bras Cardiol. 2020; 115(6):1082-1091)


Abstract Background Chagas disease (CD) is considered a public health problem in Latin America. The northeastern region, especially the state of Ceará, still represents a major concern in terms of the risk of transmission of CD. Objective To estimate the prevalence of T. cruzi in blood donors from the state of Ceará. Methods This is a retrospective descriptive study that was performed in the period from 2010 to 2015 from data recorded in the computerized system of the Hematology and Hemotherapy Center of Ceará (HEMOCE in Portuguese). Results Of the 763,731 potential blood donors, 14,159 were serologically ineligible; 1,982 (0.33%) were serologically ineligible due to positive / inconclusive diagnosis for CD. A total of 425 individuals came to the HEMOCE to repeat the test, with 28.2% (120/425) declared ineligible for donations due to CD. Conclusion No significant reduction of positive / inconclusive serology was observed in the period between 2010 and 2015, but a reduction was observed when compared to 1996/1997 in the state. The determination of the prevalence of CD in blood banks may be relevant as an indicator of the risk of CD transmission through blood transfusions in a given region. New serological tests for triage with better accuracy in screening are needed, in an attempt to reduce the unnecessary disposal of blood bags, reduce costs for the Brazilian Unified Health System, and diminish insecurity for the patient and family members. (Arq Bras Cardiol. 2020; 115(6):1082-1091)


Subject(s)
Humans , Trypanosoma cruzi , Chagas Disease/diagnosis , Chagas Disease/epidemiology , Blood Donors , Brazil/epidemiology , Antibodies, Protozoan , Prevalence , Retrospective Studies , Latin America
3.
Rev. Soc. Bras. Med. Trop ; 51(5): 616-621, Sept.-Oct. 2018. tab
Article in English | LILACS | ID: biblio-957454

ABSTRACT

Abstract INTRODUCTION: The transmission of Chagas disease (CD) through blood transfusion, organ transplantation, and oral transmission has gained greater visibility as a result of intensified vector control activities in endemic regions and to control CD in non-endemic regions. In Brazil, Ceará is one of the states that perform the most organ transplants. Therefore, the objective of this study was to assess the prevalence of Trypanosoma cruzi infection in organ donor candidates. METHODS: A retrospective analysis was performed on data from potential organ donors at the Center of Transplantation of the State of Ceará from 2010 - 2015. RESULTS: Data from a total of 2,822 potential donors were obtained, of which 1,038 were effective donors and 1,784 were excluded, likely due to lack of family authorization or medical contraindication. The prevalence of T. cruzi infection among these potential donors was 1.3% (n = 29). The majority of infected donors were males aged 41 - 60 years, residing in the interior of the state. Interestingly, 72.4% (n = 21) had positive or inconclusive serology for additional infections, such as cytomegalovirus, hepatitis B and C, and toxoplasmosis. Probability analysis revealed that stroke was the most common cause of death among potential donors with CD. CONCLUSIONS: There was a high prevalence of CD and other coinfections among potential solid organ donors in Ceará, and statistical tests have shown that these individuals are at increased risk of stroke when compared to potential non-reactive donors. This work highlights the importance of screening DC infection in potential donors.


Subject(s)
Humans , Male , Female , Child, Preschool , Child , Adolescent , Adult , Young Adult , Tissue Donors/statistics & numerical data , Trypanosoma cruzi/immunology , Antibodies, Protozoan/blood , Chagas Disease/epidemiology , Brazil/epidemiology , Seroepidemiologic Studies , Retrospective Studies , Middle Aged
4.
Ciênc. Saúde Colet. (Impr.) ; 23(5): 1483-1494, Mai. 2018. tab
Article in Portuguese | LILACS | ID: biblio-890596

ABSTRACT

Resumo O Serviço de Atenção Farmacêutica ao paciente com doença de Chagas do estado do Ceará foi criando em 2005, com a finalidade de proporcionar seguimento farmacoterapêutico àqueles com esta morbidade. Decorridos 10 anos de atuação, objetivou-se avaliar a satisfação dos pacientes atendidos no serviço. Tratou-se de um estudo prospectivo, empregando um questionário subdividido nas seções: dados socioeconômicos; infraestrutura, localização e funcionamento; cuidado farmacêutico e importância do serviço. Foram entrevistados 70 pacientes de ambos os sexos e acima de 18 anos, entre agosto de 2014 e maio de 2015. Quanto à infraestrutura, localização e funcionamento, as notas obtidas mostraram que os pacientes estão satisfeitos com os parâmetros analisados. Com relação ao cuidado farmacêutico, a maioria dos pacientes mostrou-se satisfeita, tendo o "ser bem atendido" como aspecto mais importante durante o atendimento. Em relação à importância do serviço, 100% o considerou muito importante e o indicaria para outras pessoas. De modo geral, o estudo demonstrou um alto nível de satisfação com o serviço. Há muito a ser trabalhado neste serviço, como promover maior acesso e qualificação do atendimento, contribuindo para a concretização de um modelo humanizado, centrado nas necessidades do paciente.


Abstract In 2005, a pharmaceutical care service was created in the State of Ceará to provide pharmacotherapeutic follow-up for individuals infected with Trypanosoma cruzi (Chagas Disease). After 10 years of operation, an evaluation was conducted to assess the degree of satisfaction of patients treated under the service. This prospective study used a questionnaire comprising the following sections: socioeconomic data; infrastructure, facilities and operations; pharmaceutical care; and importance of the service. Seventy patients of both sexes and over 18 years of age were interviewed between August 2014 and May 2015. As for infrastructure, location and operation, the average grades show a high level of patient satisfaction. Regarding pharmaceutical care, most patients reported being satisfied and considered "being well treated" to be the most important aspect during treatment. In addition, all patients (100%) rated the service as very important and would recommend it to other individuals. Overall, the study showed a high level of patient satisfaction with the service. There is, however, still much to work to be done on this service in order to promote greater access and qualified care to fully achieve a humanized model focused on patient needs.


Subject(s)
Humans , Male , Female , Adolescent , Adult , Young Adult , Pharmaceutical Services/organization & administration , Patient Satisfaction/statistics & numerical data , Chagas Disease/drug therapy , Socioeconomic Factors , Brazil , Prospective Studies , Surveys and Questionnaires , Middle Aged
5.
Rev. Soc. Bras. Med. Trop ; 51(2): 174-182, Mar.-Apr. 2018. tab, graf
Article in English | LILACS | ID: biblio-897071

ABSTRACT

Abstract INTRODUCTION: Chagas disease remains a public health problem in the rural and urban areas of 19 countries in the Americas. METHODS: The aim of the present study was to investigate the Trypanosoma cruzi infection rate of triatomines collected from both intra- and peridomiciliary areas in eleven municipalities of Southeastern Ceará, Brazil, from 2009 to 2015. RESULTS: A total of 32,364 triatomine specimens, including nymphs and adults, were collected, and 31,736 (98.06%) of these were examined. More nymphs were collected than adults, and the greatest number of triatomines (n = 8,548) was collected in 2010, for which the infection rate was 1.3%, with the highest rate of infections observed for specimens from Quixere. The species collected during the study were identified as Triatoma pseudomaculata, Triatoma brasiliensis, Panstrongylus megistus, Panstrongylus lutzi, and Rhodnius nasutus, with T. pseudomaculata being the most abundant (n = 19,962). CONCLUSIONS: These results verify the presence of triatomines in both intra- and peridomiciliary areas, thereby ensuring persistence of the pathogen and consequently, the disease, as the presence of infected vectors in households is an important risk factor. According to these findings, the Chagas Disease Control Program should intensify its efforts in order to prevent the spread of the disease.


Subject(s)
Animals , Panstrongylus/parasitology , Rhodnius/parasitology , Triatoma/parasitology , Insect Vectors/classification , Brazil , Retrospective Studies , Population Density , Chagas Disease/transmission , Insect Vectors/parasitology
6.
J. Health Biol. Sci. (Online) ; 5(2): 130-136, abr-jun /2017. tab
Article in Portuguese | LILACS | ID: biblio-875689

ABSTRACT

Introdução: A doença de Chagas (DC) é uma parasitose causada pelo agente infeccioso Trypanosoma cruzi. No Brasil, o tratamento específico da DC é realizado com o Benzonidazol (Bz), que devido à sua toxicidade pode levar ao aparecimento de várias reações adversas aos pacientes que fazem uso deste medicamento. Diante disso, existe uma preocupação em avaliar o paciente antes de iniciar a utilização do Bz, a fim de verificar possíveis alterações hematológicas e bioquímicas que eventualmente possam ser atribuídas à utilização deste medicamento. Objetivo: delinear o perfil dos parâmetros hematológicos e bioquímicos de pacientes com DC antes da farmacoterapia com Bz. Metodologia: Estudo retrospectivo que avaliou o perfil sociodemográfico e os parâmetros laboratoriais (eritrograma, leucograma, plaquetas, aspartato aminotransferase - TGO, alanina aminotransferase - TGP, ureia e creatinina) de 89 pacientes chagásicos crônicos atendidos no Serviço de Atenção Farmacêutica ao Paciente com doença de Chagas da Universidade Federal do Ceará no período de janeiro de 2010 a dezembro de 2015. Resultados: A população estudada se caracterizou feminina (52,8%), média de idade de 53,6 anos, de baixa renda e escolaridade, maioria aposentada, procedente do interior do estado do Ceará. No que se refere às análises hematológicas e bioquímicas, observa-se que todos os parâmetros se encontram dentro dos valores de referência. Na comparação entre gêneros, a análise estatística entre as médias demonstrou diferença significativa nos eritrócitos, no hematócrito, na hemoglobina, nas plaquetas e na contagem de linfócitos. Conclusão: Apesar da evidência de um perfil dentro dos valores normais de referência, o acompanhamento desses parâmetros laboratoriais é de suma importância no seguimento do paciente chagásico, visto que as reações adversas podem aparecer bem no início do tratamento com o Benzonidazol, levando muitas vezes à interrupção do medicamento. (AU)


Introduction: Chagas' disease (DC) is a parasite caused by the infectious agent Trypanosoma cruzi. In Brazil, the specific treatment of CD is performed with Benzonidazole (Bz), which due to its toxicity, can lead to the appearance of several adverse reactions to patients who use it. Therefore, there is a certain concern in evaluating the patient before starting the use of Bz, in order to verify possible hematological and biochemical alterations that may be attributed to the use of benzonidazole. Objective: to delineate the profile of the hematological and biochemical parameters of patients with CD before the pharmacotherapy with Bz. Methodology: Retrospective study of sociodemographic and laboratory parameters (erythrogram, leukogram, platelets, aspartate aminotransferase- TGO, alanine aminotransferase - TGP, urea and creatinine) from 89 chronic Chagas' patients treated at the Pharmaceutical Care Service of Federal University of Ceará, the January 2010 to December 2015. Results: The population studied was female (52.8%), mean age 53.6 years, low income and education, retired majority, from the interior of the state of Ceará. As far as hematological and biochemical analysis are concerned, it is observed that all parameters are within the reference values. In the comparison between genders, statistical analysis between means showed a significant difference in erythrocytes, hematocrit, hemoglobin, platelets and lymphocyte counts. Conclusion: Despite the evidence of a profile within the normal reference values, the follow-up of these laboratory parameters is of paramount importance in the follow-up of the chagasic patient, since adverse reactions may appear well at the beginning of Benzonidazole treatment, often leading to medication interruption. (AU)


Subject(s)
Chagas Disease , Biochemistry , Hematology
7.
Rev. Inst. Med. Trop. Säo Paulo ; 57(2): 145-152, Mar-Apr/2015. tab, graf
Article in English | LILACS | ID: lil-744729

ABSTRACT

By controlling the transmission of Chagas disease, the challenge of providing assistance to millions of infected patients that reach old age arises. In this study, the socioeconomic, demographic and comorbidity records of all elderly chagasic patients followed at the Pharmaceutical Care Service of the Chagas Disease Research Laboratory were assessed. The information related to the clinical form of the disease was obtained from medical records provided by the Walter Cantídio University Hospital. The profile of the studied population was: women (50.5%); mean age of 67 years; retired (54.6%); married (51.6 %); high illiteracy rate (40.2%); and family income equal to the minimum wage (51.5%). The predominant clinical forms of Chagas disease were cardiac (65.3%) and indeterminate (14.7%). The main electrocardiographic changes were the right bundle branch block (41.0%), associated or not with the anterosuperior left bundle branch block (27.4%). The average number of comorbidities per patient was 2.23 ± 1.54, with systemic arterial hypertension being the main one found (67.0%). It was found that the elderly comprise a vulnerable group of patients that associate aging with cardiac and/or digestive disorders resulting from the evolution of Chagas disease and other comorbidities, which requires special attention from health services to ensure more appropriate medical and social care.


Controlando-se a transmissão da doença de Chagas, surge o desafio de prestar assistência a milhões de pacientes infectados que chegam à velhice. Neste estudo, foram avaliados os registros socioeconômicos, demográficos e de comorbidades de todos os pacientes chagásicos idosos acompanhados no Serviço de Atenção Farmacêutica do Laboratório de Pesquisa em Doença de Chagas. As informações relacionadas à forma clínica da doença foram obtidas a partir de registros médicos disponibilizados pelo Hospital Universitário Walter Cantídio. O perfil da população estudada foi de: mulheres (50,5%); idade média de 67 anos; aposentados (54,6%); casados (51,6%); alta taxa de analfabetismo (40,2%); e renda familiar de um salário mínimo (51,5%). As formas clínicas predominantes da doença de Chagas foram a cardíaca (65,3%) e a indeterminada (14,7%). As principais alterações eletrocardiográficas foram o bloqueio de ramo direito (41,0%), associado ou não ao bloqueio ântero superior esquerdo (27,4%). O número médio de comorbidades por paciente foi de 2,23 ± 1,54, sendo a hipertensão arterial sistêmica a principal encontrada (67,0%). Verificou-se que os idosos constituem grupo vulnerável de pacientes que associam o envelhecimento com as alterações cardíacas e/ou digestivas resultantes da evolução da doença de Chagas e outras comorbidades, o que exige atenção especial dos serviços de saúde para um atendimento médico e social mais adequado.


Subject(s)
Aged , Female , Humans , Male , Middle Aged , Chagas Disease/epidemiology , Pharmaceutical Services , Brazil/epidemiology , Chronic Disease , Cross-Sectional Studies , Socioeconomic Factors
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