Study of some factors affecting the coagulant activity of cryoprecipitate

The effect of type of anticoagulants and time elapsed between donation and cryoprecipitation on the coagulant activity of cryoprecipitate were studied. A total of 90 blood units from healthy volunteers with blood group [A] were used for the test. Factor VIII content was higher in case of citrate phosphate dextrose. CPD being 97.4 +/- 21 and only 47 +/- 11.9 in case of the anticoagulant Acid - citrate dextrose. CPD blood separated after one hour, 2 hours and 3 hours showed factor VIII consents of 95.6 +/- 16, 91.1 +/- 15 consecutively. Better yield of factor VIII can be obtained if plasma is prepared as soon as possible after donation and the use of CPD as anticoagulant