ABSTRACT
Systemic fungal infections are rare. In pregnancy, treatment is problematic because of the risk of possible teratogenic effects of the antifungal drugs. We present the case of a 32 year-old woman who presented during pregnancy with a two-month history of painless subcutaneous nodules. Excision biopsy of one lesion showed dematiaceous fungal elements. Anti-fungal treatment was deferred and the pregnancy proceeded uneventfully. The remaining nodules were excised at the time of caesarean section delivery. Three weeks into the puerperium, she developed generalised seizures and investigations indicated systemic fungal infection with positive cultures for Aureobasidium spp which responded to appropriate antifungal therapy of flucytosine and itraconazole.
Subject(s)
Adult , Female , Humans , Pregnancy , Pregnancy Complications, Infectious/diagnosis , Puerperal Infection/diagnosis , Ascomycota/isolation & purification , Mycosis Fungoides/diagnosis , Pregnancy Complications, Infectious/drug therapy , Puerperal Infection/drug therapy , Skin/pathology , Tomography, X-Ray Computed , Itraconazole/therapeutic use , Flucytosine/therapeutic use , Mycoses/drug therapy , Antifungal Agents/therapeutic useABSTRACT
Four patients with bad obstetrical and with positive lupus anticoagulant tests were treated with low-dose aspirin, prednisone or heparin. They had pre-term deliveries of live babies who all survived.