Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Adenocarcinoma/complications , Adenocarcinoma/pathology , Adenocarcinoma/epidemiology , Colonic Neoplasms/complications , Colonic Neoplasms/pathology , Colonic Neoplasms/epidemiology , Postoperative Period , Rectal Neoplasms/complications , Rectal Neoplasms/pathology , Rectal Neoplasms/epidemiology , Age Factors , Sex Distribution , Karnofsky Performance Status , Mexico/epidemiologyABSTRACT
BACKGROUND: Pure mucinous adenocarcinoma of the breast is a rare entity characterized by the production of variable amounts of mucin comprising 1% to 6% of breast carcinomas. Some mucinous adenocarcinomas have shown expression of intestinal differentiation markers such as MUC-2. This study examines the expression of intestinal differentiation markers in this type of breast carcinoma. RESULTS: Twenty-two cases of pure mucinous adenocarcinoma of the breast were assessed. Immunochemistry was performed for beta-catenin, CDX-2 and MUC-2. All cases were positive for B-catenin. MUC-2 positivity was observed in all cases; 63. 6% were 3 plus positive. All cases were negative for CDX-2. CONCLUSIONS: These results suggest that mucinous breast carcinomas express some markers of intestinal differentiation, such as MUC-2 and beta-catenin; however, future studies with a larger series of cases and using molecular techniques that help affirm these results are needed.
Subject(s)
Humans , Female , Adult , Middle Aged , Aged , Aged, 80 and over , Breast Neoplasms/chemistry , Biomarkers, Tumor/analysis , Trans-Activators , Adenocarcinoma, Mucinous/chemistry , Homeodomain Proteins/analysis , beta Catenin/analysis , Mucin-2/analysis , Intestinal Mucosa/chemistry , Breast Neoplasms/pathology , Immunohistochemistry , Antigens, Differentiation/analysis , Retrospective Studies , Adenocarcinoma, Mucinous/pathology , CDX2 Transcription FactorABSTRACT
Los carcinosarcomas renales son tumores bifásicos raros (1.5 por ciento) compuestos por áreas epitelioides y fusocelulares sarcomatosas. El diagnóstico diferencial incluye lesiones primarias y metastásicas en el riñón. En este artículo se informan los hallazgos histopatológicos de inmunohistoquímica y ultraestructura, así como los criterios de diagnóstico descritos en la bibliografía