ABSTRACT
Objectives: Polycystic ovarian syndrome [PCOS] phenotypes in different races and ethnicities present with various features. This study aimed to investigate the anthropometric, clinical and biochemical differences according to the four Rotterdam phenotypes of PCOS
Design: A cross-sectional study was conducted
Setting: Two private infertility clinics and a public endocrinology clinic in Rasht, Iran
Subjects: One hundred and sixty one women with PCOS aged between 15 and 41 years from March 2010 to July 2012 were included. Polycystic ovarian syndrome was diagnosed by irregular menstruation [IM], polycystic ovary [PCO] and hyperandrogenism [HA]
Intervention: Demographic data, and fertility features were collected and anthropometric, clinical and biochemical characteristics were measured
Main outcome measures: There were significant differences in mean levels of 17-hydroxyprogesterone [P = 0.010], luteinizing hormone [P = 0.047], and ratio of luteinizing hormone / follicle stimulation hormone [P = 0.017] among the four phenotypes
Results: Most of the subjects were categorized into the IM + PCO + HA phenotype [54%], followed by IM + HA [28%], IM + PCO [13%], and PCO + HA [5%]. Among the four phenotypes, there were no significant differences in terms of demographic characters, fertility features and anthropometric measurements [P > 0.05], but there were significant differences in the prevalence of hirsutism, alopecia and morphology of PCO [P < 0.05]
Conclusion: Phenotypes of PCOS in women from Rasht are similar in most anthropometric, clinical and biochemical features
ABSTRACT
Background: The prevalence of metabolic syndrome [MetS] in polycystic ovary syn-drome [PCOS] has been studied in different populations, but their results were so con-troversial regarding Iranian women. These controversial data indicated the need for more investigation of MetS characteristics in PCOS patients in our population. So this study aimed to evaluate the clinical and laboratory characteristics and metabolic features of patients with PCOS in Rasht
Materials and Methods: This prospective cross sectional study was conducted on 215 PCOS women who lived in Rasht, north of Iran, from March 2010 to July 2012. The participants were then divided into two groups of women with MetS [n=62] and women without MetS [n=153]. The diagnosis of PCOS and MetS were based on the Rotterdam 2003 criteria and the Adult Treatment Panel III [ATP III] criteria, respectively. Demographic characteristics, fertility characteristics, family history and laboratory findings were assessed
Results: The prevalence of MetS in women with PCOS was 28.8%. In PCOS women of both groups, the waist circumference [WC] exceeded 88cm in 72.6%, hypertension [systolic blood pressure [SBP] and/or diastolic blood pressure [DBP] >/= 130/85mm Hg] was prevalent in 9.3%, fasting blood sugar [FBS] level was >/= 110 mg/dl in 6%, triglycerides [Tg] level were >/= 150 mg/dl in 47%, and high-density lipoprotein [HDL] level was <50 mg/dl in 86%. The values of WC, SBP, DBP, body mass index [BMI], ovarian size, Tg, cholesterol, FBS, 2-hour blood sugar, aspartate aminotransferase [AST], and alanine aminotransferase [ALT] were significantly greater in PCOS women with MetS than women without MetS. Also HDL and luteinizing hormone [LH] levels in women with MetS were significantly lower than women without MetS
Conclusion: Prevalence of MetS in PCOS women was 28.8%, indicating that this value is higher than other studies conducted on PCOS women in Iran and other studies conducted on general population in Iran. PCOS women are considered as a high-risk population for MetS. The special strategies are required to prevent MetS and its associated complications in PCOS women
ABSTRACT
Vaginal bleeding is a common complication during pregnancy, which is observed in about 1/4 of pregnancies and in half of cases can lead to abortion. If vaginal bleeding happens during pregnancy some adverse pregnancy outcomes, including perinatal mortality and morbidity, low birth weight and preterm delivery will be increased. The aim of this study was to determine the relationship between vaginal bleeding and its characteristics in the first and second trimester of pregnancy and preterm labor. This is a case-control study conducted on 440 pregnant women referred to Al-Zahra Hospital in Rasht, Iran. Data were collected by a form. The form included demographic characteristics and confounding factors, the occurrence of bleeding during pregnancy and its features. Data were analyzed by T test, chi square and logistic regression in SPSS 16. Findings showed that vaginal bleeding was associated with 3 times increased risk of preterm delivery [OR: 3, 1.84-4.89]. Also, findings showed that bleeding characteristics including bleeding time, frequency, severity and intensity was significantly associated with preterm labor. According to significant association between vaginal bleeding and preterm delivery, it seems that performing some interventions to prevent preterm labor could be appropriate.
Subject(s)
Humans , Female , Young Adult , Adult , Uterine Hemorrhage , Obstetric Labor, Premature , Pregnancy Trimester, Second , Pregnancy Trimester, First , Pregnancy , Case-Control StudiesABSTRACT
The aim of this study is to further compare the efficacy of PGE2 suppository, the intracervical foley catheter and extra-amniotic saline infusion in nulliparous women referred for labor induction. Totally 368 nulliparous women with a Bishop score
ABSTRACT
Women with polycystic ovary syndrome [PCOS] often are infertile and even if they become pregnant, there are complications with some adverse outcomes. It has been reported that aspirin and metformin improve uteroplacental circulation and reduce pregnancy complications. To determine and compare uteroplacental circulation and obstetrics complications in pregnant women with PCOS treated with metformin, aspirin and control group. 105 pregnant women with PCOS were enrolled in this study after assessing uterine artery pulsatility index [PI] with Doppler ultrasonography at 12 weeks of gestation. The patients were divided into three groups and received metformin 2000 mg or aspirin 80 mg daily, or no intervention until the end of pregnancy. PI was assessed for the patients at 20 week of gestation and groups were followed up till delivery. PI and obstetrics complications such as gestational diabetes, preterm labor, preeclampsia and IUGR were compared among groups. All groups had significant reduction in the mean uterine artery PI at 20 weeks measurement [p<0.05], but this reduction was more in metformin and aspirin groups than control group [p=0.002]. There was a significant difference in mean uterine artery PI 20 week of gestation in three groups [p=0.005]. Adverse outcomes have seen 4 out of 35 in metformin group, 7 out of 35 in aspirin group and 11 out of 35 in control group. There weren't significant differences among groups [p=0.12]. Metformin and low dose aspirin reduced uterine artery impedance but there was not associated with reduced obstetrics complication in women with PCOS