Carcinosarcoma expleomorphic adenoma of the parotid gland with no history of long-standing or recurrent pleomorphic adenoma - a case report / The Health Sciences Journal

Carcinosarcoma ex pleomorphic adenoma of the salivary gland is an extremely rare tumor of themajor and minor salivary glands that is composed of a mixture of both carcinomatous and sarcomatouselements with an identifiable benign epithelial and mesenchymal tumor counterpart.This report describes a rare case of carcinosarcoma ex pleomorphic adenoma involving the left parotidgland in a 61-year-old female with no history of a long-standing pleomorphic adenoma, nor a recurrentpleomorphic adenoma, and describes its morphology and important immunohistochemistry findings.Carcinosarcoma ex pleomorphic adenoma contains features of the two tumors under malignant mixedtumors, which are carcinosarcoma and carcinoma ex pleomorphic adenoma. Immunohistochemistrystudies were done to document the epithelial and mesenchymal areas from both the malignant andbenign sections of the tumor and to classify the carcinoma and sarcoma component, consisting ofadenocarcinoma, not otherwise specified for the carcinoma component, and myxoid chondrosarcomaand mesenchymal chondrosarcoma for the sarcoma component.The paucity of documented cases of carcinosarcoma ex pleomorphic adenoma in prior scientificpublications requires reporting cases such as this. Furthermore, the report provides an insight intothe more complex molecular and structural changes that manifest as cancer behavior in the tumorsof the salivary gland. The case contributes to the fund of knowledge for diagnosis and improvementof quality of care.

Primary serous papillary carcinoma arising from the omentum with metastasis to the parametrium and bilateral ovarian and fallopian tube serosal surface: A case report / The Health Sciences Journal

INTRODUCTION@#Primary peritoneal serous carcinoma is a rare, malignant, epithelial tumor arising from the peritoneum and associated tissues, that presents commonly with diffuse peritoneal involvement and ascites. Carsinomas that morphologically resemble papillary serous carcinoma of the ovary, with uninvolved and minimally involved ovaries, with lesion of the peritoneum larger than other primary ovarian lesions, and with no other identifiable primary tumor, are categorized under such. The aim of this report is to contribute to the fund of knowledge pertinent to this rare lesion with a relatively poor prognosis.

Metastatic mammary carcinoma in a mature singleton placenta / The Health Sciences Journal

Introduction@#Placental metastasis from maternal malignancies is a rare occurrence with a significantly adverse prognosis on the mother with no known effect or established risk factors for the newborn. As such, characterization of these lesions is necessary to serve as a stepping stone for more exhaustive studies regarding this presentation.@*Case Summary @#This is a case of a metastatic breast carcinoma in a mature singleton placenta in a 39 year old woman diagnosed with invasive breast carcinoma of no special type/invasive ductal carcinoma, not otherwise specified, during the second trimester of pregnancy. Also discussed are the immunohistochemistry studies done to confirm the origin of the tumor. A comparison of the ER, PR, and HER2/neu receptor status between the primary lesion and the placental metastasis was also done.@*Conclusion @#Pregnancy-associated breast cancer is a lesion that carries adverse prognosis for the mother because of the delay in diagnosis attributable to confusion of symptomatology. The pertinent problem in pregnancy-associated breast cancer with placental metastasis is the deficiency of the placenta to induce tumor metastasis away from itself.