ABSTRACT
Introduction: The evolution of chemo and radiotherapy, added to the increased frequency in its use, have led to an increase in the survival rate of pediatric patients with head and neck cancer. Thus, the effects of this therapy are increasingly common, and may affect even the teeth in formation. Objective: Conduct a literature review on the main dental anomalies of development in patients undergoing chemo and radiotherapy. Material and methods: The databases "Pubmed", "Google Scholar" and "Science Direct" were consulted using the keywords "dental alterations", "children", "dentistry", "cancer", "chemotherapy" and " radiotherapy". Twenty-seven articles published in English were selected. Results: Based on the articles included in the study, the effects of chemoradiotherapy on developing teeth can be both quantitative and qualitative. Those patients who underwent treatment during childhood, in this literature review, were between 0.8 and 15 years old. The main dental anomalies found include microdontia, hypodontia and root anomalies. In addition, it was also observed that the late effects of the therapy vary according to the radiation dose and the chemotherapy dose. Conclusions: Although there are few studies on dental alterations caused by chemotherapy and radiotherapy, it is necessary to implement protocols aimed at oral care during and after treatment to reduce the incidence and severity of such complications. (AU)
Subject(s)
Humans , Child, Preschool , Child , Radiotherapy , Child , Dentistry , Tooth , Drug Therapy , NeoplasmsABSTRACT
O objetivo do presente estudo foi avaliar a eficácia clínica e histopatológica da terapia fotodinâmica (TFD) associada à terapia a laser de baixa potência no tratamento de pacientes com queilite actínica (QA) após seis meses de acompanhamento. Material e Métodos: pacientes com QA ativa foram submetidos a duas sessões de TFD associadas à laserterapia de baixa potência, utilizando o 5-aminolevulinato de metila como droga fotossensibilizadora. Após seis meses de acompanhamento, uma nova biópsia incisional foi realizada para avaliar a resposta ao tratamento. Resultados: excelentes taxas de eficácia foram observadas na melhora dos sintomas neste estudo, no entanto, a análise histopatológica não foi tão promissora e apenas a melhora do grau de displasia só pode ser observada em 20% da amostra. Conclusão: de acordo com os resultados do presente estudo, pode-se concluir que a terapia fotodinâmica associada à laserterapia de baixa potência parece ser uma opção a ser considerada no tratamento da Queilite Actínica. No entanto, os pacientes devem ser acompanhados de perto clinicamente e, eventualmente, histopatologicamente
Objective: the aim of the present study was to evaluate the clinical and histopathological efficacy of photodynamic therapy (PDT) associated with the low-level laser therapy (LLLT) in the treatment of patients with Actinic Cheilitis (AC) after a six-month follow-up. Material and Methods: patients with active AC undergone through two sessions of PDT, associated with the low-level laser therapy using the Methyl 5-aminolevulinate as a photosensybilizer drug. After a six-month follow-up, a new incisional biopsy was performed in order to evaluate the response to treatment. Results: excellent efficacy rates were observed in the improvement of symptoms in this study, however, histopathological analysis was not so promising and the improvement of dysplasia degree could only be seen in 20% of the sample. Conclusion: according to the results of the present study, we concluded that the photodynamic therapy associated with low-level laser therapy is an option to be considered when treating Actinic Cheilits. However, patients should be clinically followed-up in a severing agenda and eventually, histopathologically