ABSTRACT
Objective To observe the clinical efficacy and safety of Yiqi Huoxue Huatan Yangxin (IHHY) Decoction for treatment of unstable angina pectoris patients. Methods Totally 165 cases of patients with unstable angina pectoris were collected and divided into observation group (84 groups) and control group (81 patients) by semi-random method. Patients in both groups received western medical, and patients in observation group were added with IHHY Decoction, one dosage a day, twice a day, orally. The therapeutic course for both groups was 4 weeks, with 4 weeks follow up. Angina pectoris grade and ECG effect in both groups were observed. Blood viscosity, fibrinogen, serum NO, superoxide dismutase (SOD), plasma levels of endothelin (ET), thromboxane B2 (TXB2), 6-keto-PGF1α, were measured, and TCM syndrome score was observed. The incidence of all adverse reactions was recorded. Results After treatment, the angina pectoris grade of both groups were lower than before, with statistical significance (P<0.05). The total effective rate of ECG was 69.0% (58/84) in the observation group and 65.4% (53/81) in the control group, without statistical significance (P>0.05). Compared with before treatment, whole blood viscosity, plasma fibrinogen, levels of ET and TXB2 decreased, while the levels of NO and 6-keto-PGF1αincreased (P<0.05). Whole blood viscosity, plasma fibrinogen, levels of ET and TXB2 in the observation group were lower than the control group after treatment, while the level of NO was higher than the control group, with statistical significance (P<0.05). There was no statistical significance in TCM syndrome before and after treatment in both groups. There was no abnormality in liver and kidney. Conclusion On the basis of routine treatment, IHHY Decoction can significantly relieve the symptoms of unstable angina and maintain the balance of vasoconstriction and platelet aggregation.
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the effect of Shin-I essential oil inhalation on blood lactate changes in rats subjected to treadmill exercise.</p><p><b>METHODS</b>: Adult male Sprague Dawley rats (n=12) were randomly divided into the control or the Shin-I group. Rats were subjected to a treadmill exercise program (15 m/min for 30 min). After exercise, rats were exposed to 200 µL of water or Shin-I essential oil, respectively, using a nebulizer for 180 min during the recovery period. Blood samples were collected every 15 min. Blood glucose and lactate concentrations were determined in a CMA 600 analyzer.</p><p><b>RESULTS</b>: The basal glucose and lactate levels were no significantly different between two groups. After exercise, glucose levels were slightly increased to about 110%-120% of the basal level in both groups. Lactate levels of both groups reached to 110%-140% of basal levels during exercise. In the recovery period, lactate levels further increased to 180% of the basal level and were maintained at a plateau in the control group. However, lactate levels gradually decreased to 60%-65% of the basal level in the Shin-I group. Lactate clearance was significantly enhanced after Shin-I essential oil inhalation.</p><p><b>CONCLUSIONS</b>: Our results provide evidence that Shin-I essential oil inhalation may accelerate recovery after exercise in rats.</p>