Animal model of nonalcoholic fatty liver disease: Research advances / 国际药学研究杂志

Non-alcoholic fatty liver disease(NAFLD)represents a syndrome of liver disease encompassing steatosis, non-alcoholic steatohepatitis(NASH), fibrosis and cirrhosis in the absence of alcohol abuse. NAFLD is now emerging as a common medical problem due to its high incidence and the difficulty of treatment. To date, the pathogenesis of NAFLD has not been well elucidated, and few effective therapeutic approaches for NAFLD are available. Therefore, to develop high-quality animal models of NAFLD is important to enhance our understanding of its pathogenesis. This review summarizes animal models used in recent years in NAFLD study and introduces their making method and characteristics.