ABSTRACT
Objective:To observe the clinical effect of Banxia Xiexin decoction combined with clarithromycin and tinidazole in the treatment of pediatric gastritis.Methods:From March 2017 to November 2018, 100 children with gastritis admitted to the First People's Hospital of Wenling were selected.They were divided into control group (50 cases) and observation group (50 cases) by random number table method.The control group was treated with conventional western medicine.The observation group was treated with Banxia Xiexin decoction combined with clarithromycin and tinidazole.Both two groups had the same course of treatment for two weeks.The symptom score, quality of life score, epigastric fullness, epigastric pain and acid reflux disappearance time were observed before and after treatment.The clinical efficacy and adverse reactions were compared between the two groups.Results:Before treatment, there were no statistically significant differences in the scores of gastritis symptoms and quality of life between the two groups (all P>0.05). After treatment, the scores of gastritis symptoms and quality of life in the control group were (1.27±0.22)points and (80.22±4.45)points, respectively, which in the observation group were (0.56±0.11)points and (90.53±4.11)points, respectively, the differences between the two groups were statistically significant( t=5.824, 7.825, all P<0.05). The disappearance time of upper abdominal fullness, pain and acid reflux in the control group were (5.42±2.51)d, (4.47±2.24)d, (4.68±1.51)d, respectively, which in the observation group were (4.11±1.12)d, (3.25±1.21)d, (3.21±0.24)d, respectively, the differences were statistically significant between the two groups( t=5.221, 5.167, 5.121, all P<0.05). The total effective rate of the observation group was 98.00% (49/50), which was higher than 80.00% (40/50) of the control group (χ 2=8.201, P<0.01). The incidence of adverse reactions in the observation group was 6.00%(3/50), which was lower than that in the control group [18.00% (9/50)] (χ 2=6.278, P<0.05). Conclusion:Banxia Xiexin decoction combined with clarithromycin and tinidazole can effectively improve the clinical symptoms, gastric function and quality of life of children with gastritis, with fewer adverse reactions, and the effect is better than conventional western medicine.
ABSTRACT
Objective To investigate the clinical effect of alprostadil in the treatment of coronary heart disease and its effect on myocardial microcirculation and hemorheology.Methods From January 2015 to October 2017,100 patients with coronary heart disease admitted to the First People's Hospital of Wenling were randomly divided into two groups according to the digital table,with 50 cases in each group.The control group was treated with routine therapy.The observation group was treated with alprostadil on the basis of routine treatment.The clinical efficacy,myocardial microcirculation index and hemorheology index were compared between the two groups.Results The total effective rate of the observation group was 96％ (48/50),which was higher than 82％ (41/50) of the control group,and the difference between the two groups was statistically significant (x2 =5.005,P ＜ 0.05).After treatment,the cardiac troponin Ⅰ and myocardial troponin T in the observation group were (0.023 ±0.014)μg/L,(0.012 ±0.006)μg/L,respectively,which in the control group were (0.037 ± 0.015) μg/L,(0.019 ± 0.008) μg/L,respectively,the differences between the two groups were statistically significant (t =4.825,4.950,all P ＜ 0.05).The erythrocyte hematocrit,plasma viscosity,erythrocyte sedimentation rate,erythrocyte electrophoresis time in the observation group were (25.69 ± 3.87) ％,(293.42 ± 12.73) s,(15.21 ± 4.59) mm/h,(1.29 ± 0.37) mp/s,respectively,which in the control group were (32.54 ± 4.52) ％,(326.17 ± 18.65) s,(21.85 ± 5.93) mm/h,(1.76 ± 0.43) mp/s,respectively,the differences between the two groups were statistically significant (t =8.140,10.256,6.261,10.256,all P ＜ 0.05).Conclusion Alprostadil in the treatment of coronary heart disease can improve the clinical efficacy and improve the patients'myocardial microcirculation and hemorheological indicators.
ABSTRACT
Objective To investigate the effect of Shenqi Fuzheng injection on serum CRP,IL-6 and IL-10 levels in elderly patients with coronary heart disease.Methods 64 elderly patients with coronary heart disease from Wenling First People's Hospital hospital were selected and randomly divided into the control group and the experiment group.32 cases in each group, the control group were treated by conventional symptomatic treatment, the experiment group were treated with Shenqi Fuzheng injection on the base of control group.The serum ( C-reactionprotein,CRP) ,white blood cell mediated IL-6 and leukocyte mediated element IL-10, systolic blood pressure, diastolic blood pressure(DBP),glycerin,total cholesterol(TC),triglyceride(TG), low density lipoprotein(LDL-C) and high density lipoprotein(HDL-C) levels were recorded,and the clinical efficacy and adverse reaction conditions were compared.Results The effective rate of treatment in the control group was 68.75% lower than that in the experiment group 90.63%(P<0.05). Compared with the control group after treatment,the serum CRP, IL-6, IL-10, systolic blood pressure, diastolic blood pressure, TC,TG and LDL-C levels were lower,theHDL-C level was higher,has statistical significance(P<0.05).Conclusion Shenqi Fuzheng injection in the treatment of elderly patients with coronary heart disease has a significant effect,can reduce serum CRP, IL-6 and IL-10 levels.