ABSTRACT
The clinical efficacy and the safety of ofloxacin i.v. in 35 acute symptomatic urinary tract patients were evaluated. The drug was intravenously administered, 400 mg starting dose then 200 mg once-daily for 3-5 days. The therapeutic success rate and eradication rate in UTI case were 100 per cent in all cases when evaluated immediately after completion of drug treatment, therapeutic success rate and eradication rate at the follow-up evaluation were 97.2 per cent and 91.6 per cent respectively. Also, 5 cases of acute bronchitis and 2 salmonellosis were also administered intravenously, 400 mg once-daily dose and 400 mg twice daily dose respectively. No serious side effects of ofloxacin i.v. therapy were observed in any of our patients.
Subject(s)
Acute Disease , Adolescent , Adult , Aged , Bacterial Infections/diagnosis , Dose-Response Relationship, Drug , Drug Administration Schedule , Female , Humans , Injections, Intravenous , Male , Middle Aged , Ofloxacin/administration & dosage , Prognosis , Treatment Outcome , Urinary Tract Infections/diagnosisABSTRACT
Thirty-five women with uncomplicated acute lower urinary tract infections proven by significant pre-treatment bacteriuria (> or = 10(5)CFU/ml) were treated with an oral dose of 100 mg cefixime twice a day for seven days. Thirty five patients included in this study were checked for response to treatment on the last day of therapy, 7-14 days and 4 weeks post therapy. The clinical response and bacterial eradication rate for cefixime were 91.4 per cent (32/35). The infecting organisms, E. coli and Proteus mirabilis, were inhibited at MIC90 = 0.5 and < or = 0.03 microgram/ml, and MBC = 1 and 0.06 microgram/ml respectively. No adverse events were found in this study.
Subject(s)
Adult , Aged , Cefixime , Cefotaxime/administration & dosage , Cephalosporins/administration & dosage , Drug Administration Schedule , Female , Humans , Microbial Sensitivity Tests , Middle Aged , Urinary Tract Infections/drug therapyABSTRACT
Thirty patients with acute urinary tract infection were treated orally with 500 mg of cefaclor three times a day for 7 days. Urine cultures were made before treatment and after therapy. In 97 per cent (29/30) of these patients clinical success was achieved and in 90 per cent (27/30) of them, pathogens were eradicated. Our study showed that cefaclor was still active against most Enterobacteriaceae, such as Escherichia coli and Klebsiella species, the principle pathogens of urinary tract infection. No adverse effects of cefaclor were observed in this study.