ABSTRACT
Objective To investigate the changes of plasma protein Z and coagulation factor Ⅷ activity in children with primary nephrotic syndrome.Methods 94 children with primary nephrotic syndrome were se-lected as the observation group,and 63 healthy children were selected as the control group.The blood samples of peripheral blood were collected from the study group,and plasma protein Z and coagulation factor Ⅷ were measured by enzyme linked immunosorbent assay.Enzyme linked immunosorbent assay was used to measure plasma protein Z and coagulation factor Ⅷ.The changes of plasma protein Z and coagulation factor Ⅷ in the two groups were compared,and the changes of plasma protein Z and coagulation factor Ⅷ in the acute and re-covery phase,and the correlation between plasma protein Z and coagulation factor Ⅷ were observed.Results The observation group of plasma protein Z level is lower than the control group,blood coagulation factor Ⅷlevels higher than the control group,and the difference was statistically significant(P<0.05);plasma protein Z level in acute stage is lower than the recovery period,and coagulation factor Ⅷ level is higher than the recov-ery period,the differences were statistically significant(P<0.05);plasma protein Z and coagulation factor Ⅷwas negatively correlated.Conclusion The plasma protein Z level in children with primary nephrotic syn-drome is significantly reduced,and the activity of coagulation factor Ⅷ is significantly increased.Detection of plasma protein Z and coagulation factor Ⅷ level can predict primary nephrotic syndrome in children.