ABSTRACT
Objective To investigate the correlation between the expression of IL -17,18,32 as well as the lung adenocarcinoma antigen KL -6 and the severity of patients with acute exacerbations of chronic obstructive pulmonary disease (AECOPD).Methods Totally 120 AECOPD patients treated in our hospital (Zhejiang Rongjun Hospital) form Jan 2014 to Jan 2016 were selected.Among them,the condition of 50 cases got controlled after treatment(group A),while other 70 cases did not get controlled(group B).At the same time,26 healthy people were selected as control group.The expression levels of IL -17,18,32 and KL -6 in the blood of there groups were detected by ELISA.Results The IL -17,18,32,KL -6 levels of group A were (49.07 ±17.22)pg/mL,(156.38 ±24.41)pg/mL, (11.63 ±4.05)pg/mL,(106.62 ±13.74)pg/mL,which were significantly higher than those of the control group [(32.32 ±3.04)pg/mL,(134.83 ±18.92)pg/mL,(9.26 ±3.35)pg/mL,(65.24 ±15.51 )pg/mL,t =4.905, 3.926,3.561,11.916,all P <0.05].The IL -17,18,32,KL -6 levels of group B were (92.68 ±13.25)pg/mL, (357.44 ±26.35)pg/mL,(50.10 ±9.88)pg/mL,(285.64 ±25.40)pg/mL,which were significantly higher than those of group A,the differences were statistically significant between the two groups (t =15.674,42.479,25.995, 45.293,all P <0.05 ).Conclusion The expression levels of IL -17,18,32 and lung adenocarcinoma antigen KL -6 are elevated with the increased severity of AECOPD patients.Therefore,the expression levels of these four indicators can be used to evaluate the severity of AECOPD patients.
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Objective To investigate the clinical effect of linezolid in the treatment of pulmonary infection with methicillin resistant Staphylococcus aureus (MRSA).Methods 74 cases of pulmonary infection with MRSA were selected and randomly divided into control group and study group, 37 cases in each group.The control group received norvancomycin(1.0 g per time,twice daily) and the study group received linezolid (600 mg per time, twice daily) , with a consecutive treatment of 2 weeks.The inflammatory factors and related laboratory indicators were detected, the clinical efficacy, bacterial clearance rate and adverse reaction conditions were compared after the treatment.Results Compared with before treatment, serum levels of CRP, IL-1, IL-6 and TNF-αdecreased(P<0.05), levels of serum PCT, ET, NO and Lac decreased(P<0.05), compared with the control group, serum levels of CRP, IL-1, IL-6 and TNF-αin the study group were lower(P<0.05), levels of serum PCT, ET, NO and Lac were lower(P<0.05). There was no statistical difference in clinical efficacy rate between study group and control group (91.89% vs.81.08%), bacterial clearance rate of control group ( 70.27%) was lower than that the study group ( 89.19%) , and the difference was statistically significant ( P <0.05 ) . Conclusion Linezolid in the treatment of MRSA was effective with high safety, and it could reduce serum inflammation index.
ABSTRACT
Objective To observe the clinical effect of Salmeterol xinafoate and fluticasone propionate powder for inhalation in patients with chronic obstructive pulmonary disease.Methods 70 patients diagnosed with chronic obstructive pulmonary disease from March 2014 to March 2015, were randomly divided into two groups ( n =35 ) .Control group were given basic treatment, observation group was given Salmeterol xinafoate and fluticasone propionate powder for inhalation on the basis of control group , patients were followed up and changes of related indicators wererecorded. Results After treatment one month, serum airway remodeling index b-FGF, TIMP-1 values were (93.86 ±17.36 μg/L, 38.06 ±4.28ng/mL) respectively, more than control group(135.03 ±16.06μg/L, 53.95 ±4.15ng/mL)(P<0.05).After treatment one month, inflammatory markers IL-8, TNF-αwere(7.26 ±1.57 pg/mL, 4.29 ±1.02 ng/L)respectively, were more than the control group (14.27 ±1.71 pg/mL, 8.90 ±1.21 ng/L) (P<0.05).After treatment, the observation group, the total effective rate was 91.43%, higher than 77.14%(P <0.05).Conclusion Salmeterol xinafoate and fluticasone propionate powder for inhalation has good effect in treatment of chronic obstructive pulmonary disease , better than the use of basic treatment alone.