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Background Behcet's disease is a refractory panuveitis with high blindness rate.Multifocal electroretinography (mfERG) is a useful tool for the evaluation of the function of the posterior retina.ObjectiveThe aim of this study is to assess the characteristics of Behcet's disease using the mfERG.Methods mfERG was recorded in 68 eyes of 39 cases with active stage of Behcet's disease.All of the patients were diagnosed based on the Standard of International Study Group for Behcet's Disease and assigned to the cystoid macular edema (CME) group and the diffuse macular edema (DME) group after assessment by fundus fluorescein angiography (FFA).Seventeen normal subjects were used as controls.Oral informed consent was obtained from all of the subjects prior to this trial.mfERG recording followed the ISCEV Guidelines for Clinical Multifocal Electroretinography (2007 edition).The response density and latency of P1 and N1 waves in 6 rings were analyzed and compared.Results The amplitudes of N_1 waves from rings 1 through 6 and N1 wave from rings 1 through 5 were significantly declined in patients with Behcet's disease compared with normal control (P＜0.01).All of the latencies of P_1 waves from rings 1 through 6 were insignificantly shortened in patients with Behcet's disease compared with normal control (P＞0.05).The amplitudes of P_1 and N_1 waves from rings 1 through 6 in diffuse macular edema group were considerably lower than those in the cystoid macular edema group (P＜0.05,P＜0.01).A test of visual acuity showed a negative correlation to the amplitude and latency of N_1 wave (r=-0.36,-0.37,P＜0.05 ) and a positive correlation with the amplitude of N1 wave (r=0.43,P＜0.05) in the DME group.In the CME group,a test of visual acuity presented a negative correlation to the amplitude and latency of N1 wave and latency of P1 (r=-0.41,-0.35,-0.40,P＜0.05 ) and a positive correlation with the amplitude of P1 wave (r=0.48,P＜0.05).Conclusion mfEGR demonstrates that retinal electro-activity is abnormal in eyes with Behcet's disease.The distinct functional disorder is situated around the fovea.
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Objective To investigate the influence of experimental scotoma on multifocal visual evoked potential (mf-VEP). Methods The mf-VEP of 10 healthy individuals (20 eyes) was measured with VERIS Science 4.0. Every eye was measured for 3 times. The right eye was measured with full field stimulation and upper hemi-field or lower hemi-field masked. The left eye was measured with full field stimulation and central three-rings area or lower nasal field masked. The first slice responses of the second order in different field were analyzed and compared by VERIS software. Results The mf-VEP in masked area was undetectable or obviously decreased in all subjects. In most unmasked field, the amplitudes of mf-VEP were not changed, except that in some place decreased slightly with statistically significant difference in comparison to the full field stimulation mode. Conclusion mf-VEP is influenced with experimental scotoma. The mf-VEP changes are consistent with the visual field masked.
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<p><b>OBJECTIVE</b>To investigate the characteristics of multifocal electroretinograms (mf-ERG) of different phases in diabetic retinopathy (DR) and its clinical significance.</p><p><b>METHODS</b>Multifocal electroretinograms in patients with DR (I - II stage) were tested with VERIS IV system.</p><p><b>RESULTS</b>In I - II stage, the absolute values of N1, P1 and N2 response densities, and the N1-P1 and P1-N2 response densities were attenuated is a field of about 45 degrees in diameter.</p><p><b>CONCLUSION</b>As a new objective and quantitative examination for spatial visual function, multifocal electroretinograms may be valuable in the diagnosis of diabetic retinopathy.</p>
Subject(s)
Aged , Female , Humans , Male , Middle Aged , Diabetic Retinopathy , Pathology , Electroretinography , Methods , Retina , Pathology , Time FactorsABSTRACT
Objective To measure and compare the difference between the normal control and retinoschisis with multifocal electroretinography. Methods Nineteen cases (21 eyes) of normal control and 8 cases (15 eyes) of inherited retinoschisis were measured with VERIS Science TM 4.0. Three cases (6 eyes) of inherited retinoschisis were tested with Ganzfeld ERG. Results There was statistically significant difference of average response density and latencies in all 6 ring retinal regions between the normal control and retinoschisis. The topography of multifocal ERG showed that multifocal amplitude decreased with disappearing or decreasing of central peak amplitude in patients with retinoschisis. The P 1/N 1 ratio of the multifocal ERG average response densities in 6 ring retinal regions was different from the b/a ratio of the Ganzfeld ERG. Conclusion Each of the multifocal ERG and Ganzfeld ERG has its advantage in the diagnosis of the retinoschisis.
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Purpose To measure and compare the difference of multifocal electroretinogram in normal subjects and patients with age related macular degeneration. Methods Seventeen cases(20 eyes)of normal subjects,7 cases(10 eyes)of dry form AMD(age related macular degeneration),8 cases(8 eyes)of wet form AMD and 11 cases(11 eyes)of idiopathic macular hole(IMH)were tested with VERIS Sciences TM 4.0 made by EDI company of America.The latencies and average response densities of 6 ring retinal regions in normal subjects were compared with those in various types of age related maculopathies. Results The N 1 and P 1 wave latencies of all 6 rings in wet form AMD and the N 1 wave latencies of 3～6 rings in dry form AMD were delayed statistically.The N 1 and P 1 wave average response densities of 1～4 rings in and the P 1 wave average response densities of 1～6 rings wet form AMD and the N 1 wave average response densities of 1～5 and the P 1 wave average response densties of 1～6 rings in dry form AMD were decreased statistically.The N 1 and P 1 wave average response densities of 1～2 and the P 1wave average response densities of 1～3 rings were decrease statistically in IMH. Conclusion Multifocal electroretinogram can be used to quantitate the visual function of the affected location in age related macular degeneration.
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Objective To explore the clinical application value of multifocal oscillatory potentials (MOPs) in retinal vein occlusion (RVO). Methods MOPs were tested using VERIS 4.0 visual evoked response imaging system for 19 cases (19 eyes) of RVO,among them 8 cases of central retinal vein occlusion (CRVO) and 11 cases of branch retinal vein occlusion (BRVO). Twenty normal subjects were as normal control group. The stimulative visual angles subtended ?26.6? horizontally and ?22.1? vertica lly. The filter setting was bandpass 100～1 000 Hz. The retinal responses from 103 hexagons were recor ded in 4 min (8 segments). Results In normal control group, OP 1, OP 2 and OP 3 were recorded during 37 ms for first order and 47 ms for second order first slice in whole test field and 5 ring retinal regions, the oscillatory wave shapes of second order were clearer than those of first order. In RVO groups, 91.6% latencies of OP 1, OP 2 and OP 3 were delayed, and 70.8% amplitudes of OP 1, OP 2 and OP 3 were reduced. The delay of the latencies and the decrease of the amplitude in CRVO were more markedly than those in BRVO. Conclusion MOPs can be effectively and quantitatively used to evaluate the retinal function of the different location in RVO.