ABSTRACT
Objective:To investigate the current status of health checkups and the management willingness of post-test abnormal values in residents of mega communities, and to explore the factors affecting the demand for health management of abnormal values after examination.Methods:A cross-sectional study. The residents of Huaguoyuan Community in Guiyang City were enrolled as the objects of this surveywith stratified systematic sampling method and questionnaire survey. The binary logistic regression was used to analyze the influencing factors of health management demand for abnormal values after examination.Results:There were 404 residents participating in this survey, and 182 cases were male (45.05%) and 222 cases were female (54.95%); the mean age was (39.64±15.03) years. There were 179 (44.31%) urban residents and 225 (55.69%) rural residents. There were 162 (40.10%) floating population and 242 (59.90%) non-floating population. Of the residents, 34.2% participated in the physical examination independently due to physical reasons. The age ( χ 2=16.227), household registration ( χ 2=16.117) and occupation ( χ 2=36.454) had statistically significant differences in residents′ participation in physical examination; the household registration ( χ 2=18.726, P<0.001) and occupation ( χ 2=18.094, P=0.034) had significant differences in the handling methods of abnormal values of physical examination. The age ( OR=7.00, P=0.032) and income ( OR=0.33, P=0.047) were the influencing factors of health management needs of abnormal values after health checkup. Conclusion:The awareness of active physical examination of residents in mega community is weak, and it is recommended to strengthen health education and health promotion; residents have a high willingness to the management of abnormal values after health checkup, it can be an important supplement to improve the service quality of physical examination related institutions.
ABSTRACT
Retinopathy of prematurity (ROP) is a blinding eye disease characterized by abnormal proliferation of retinal blood vessels in children.Vascular endothelial growth factor (VEGF) can specifically stimulate retinal vascular endothelial cell proliferation and neovascularization.Retinal ischemia and hypoxia in preterm infants promote the compensatory increase of intraocular VEGF expression, and then induce the pathological growth of retinal vessels.The intravitreal injection of anti-VEGF drugs provides a new therapeutic way for ROP by inhibiting the biological activity of VEGF and delaying retinal neovascularization.However, the blood-retina barrier of children with ROP is likely to be destructed, which can cause the imbalanced homeostasis of the retinal microenvironment.The anti-VEGF drugs can cause irreversible damage to nerve cells through the blood-retina barrier and blood-brain barrier, which affects the development of the nervous system in children with ROP.At present, whether anti-VEGF drugs result in the abnormal development and functional changes of nervous system in premature infants remains unknown and attracts much attention.In this paper, the role of VEGF in the pathogenesis of ROP and neurodevelopment, as well as the effects of anti-VEGF drug intravitreal injections on the neurological development of children with ROP were reviewed to provide the clinical basis for the rational and safe application of anti-VEGF drugs.