Heterogenous phase as a mean in combinatorial chemistry

Combinatorial chemistry is a rapid and inexpensive technique for the synthesis of hundreds of thous and s of organic compounds of potential medicinal activity. In the past few decades a large number of combinatorial libraries have been constructed, and significantly supplement the chemical diversity of the traditional collections of the potentially active medicinal compounds. Solid phase synthesis was used to enrich the combinatorial chemistry libraries, through the use of solid supports [resins] and their modified forms. Most of the new libraries of compounds appeared recently, were synthesized by the use of solid-phase. Solid-phase combinatorial chemistry [SPCC] is now considered as an outst and ing branch in pharmaceutical chemistry research and is used extensively as a tool for drug discovery within the context of high-throughput chemical synthesis. The best general pure libraries synthesized by the use of solid phase combinatorial chemistry [SPCC] may well be those of intermediate complexity that are free of artifact-causing nuisance compounds

role of soluble intercellular adhesion molecule-1 [SICAM-1] in bronchial asthma

SICAM-l is present in the serum of healthy individuals and its level may be elevated during inflammatory diseases or malignancy. Recent studies have suggested that lCAM-l may be involved in the pathogenesis of bronchial asthma. Hence, this work was carried out to determine weither bronchial asthma is associated with increased serum levels of slCAM-l and to assess the effects of therapy on their levels.Serum levels of slCAM-l was measured in a well known asthmatic patients and in healthy control subjects.Mean value +/- SD of sICAM-l levels in sera of asthmatics [294.2 +/- 94.7 nglml] was significantly higher [P <0.01] than that for healthy subjects [220.6:1 +/- 57.7nglml]. Serum slCAM-1 levels among atopic asthmatics showed a non significant difference [P > 0.05] than those with non atopics [316.2 +/- 12.3 and 274.8 +/- 57.8 respectively]. A significant reduction [P < 0.01] in the serum levels of sICAM-l were observed during remission than during attack among asthmatic parients treated by steroids [199.1 +/- 44.8 ng/ml and 259.4 +/- 40.16 ng/ml respectively], while those not received steroid in their management proved a non- significant reduction [P > 0.05] in serum levels of sICAM-I in remission than during attack [257.3 +/- 49.5 ng/ml and 284 +/- 72.5 ng/ml respectively]

Synthesis and reactions of 2-chloromethyl-6-iodo-3, 1-benzoxazin-4-one with amines

Certain quinazolinones were reported to exert antimicrobial activity[1]. Consequently, in continuation of our previous work on the reaction of 3,1-benzoxazin-4-ones with amines,[2-5], 2-chloromethyl-6- iodobenzoxazin-4-one was synthesized and allowed to react with amines hoping to obtain 4-quinazolinones for evaluation as antimicrobial agents. 5-Iodoanthranilic acid was chloroacetylated to give I which was cyclodehydrated to yield the corresponding 3,1-benzoxazin-4- one II Compound II was allowed to react with different aromatic amines to produce 3-aryl-2-chloromethyl-6-iodoquinazolin-4-ones IIIa-t. Structures of compounds III [Scheme 1] were confirmed by microanalytical and spectroscopic data [Table1 and 2]

Repair of septal perforation by conchal cartilage free graft

Nasal septal perforation of various etiologies have been seen by most otolaryngologists. Those perforations which are asymptomatic or controlled by medical management do not required further attention. Surgical management is usually for the perforations that continue to cause whistling, crusting and bleeding. Patients with nasoseptal perforations were chosen from outpatient clinic of Zagazig University Hospitals. All were subjected to clinical examination and laboratory investigations followed by repair with conchal cartilage as a free graft and follow up for 3 months. Seven out of ten cases were successfully repaired with complete closure of perforation and relief of symptoms. Three cases were unsuccessful, in one case the perforation did not take the graft completely and in the other two cases, perforations were smaller than before. From the present study it is concluded that utilization of this procedure in appropriate cases of septal perforations less than 2 cm in diameter is very helpful in most of the cases