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1.
Medical Journal of Cairo University [The]. 2009; 77 (1): 495-505
in English | IMEMR | ID: emr-100961

ABSTRACT

Hepatitis C virus [HCV] infects more than 170 million people worldwide and around 20% of blood donors are seropositive by ELIZA to HCV Ab in Egypt. Renal manifestations may be the presenting features of chronic HCV infection. This work was carried out on 200 patients with chronic HCV in order to study the relationship between HCV and chronic kidney Disease and to stratify HCV patients according to the degree of albuminuria and to know the histopathological changes in kidney and liver by immunohistochemical study. II showed that screening for proteinuria in patients with chronic HCV is necessary due to high prevalence of renal affection in these patients. Assessment of microalbuminuria should be done in these patients as an early indicator for renal affection. Albumin creatinine ratio ACR] had a good reliability as a surrogate measure for routine screening of urine albumin excretion. Awareness of chronic kidney disease [CKD] stage in patients with HCV and renal affection help prediction and early management of renal disease. There was a documented link between cryoglobulinemic and non-cryoglobulinemic membrano-proliferative glomerulonephritis and HCV infection


Subject(s)
Humans , Male , Female , Albuminuria , Liver/diagnostic imaging , Kidney/diagnostic imaging , Biopsy , Immunohistochemistry , Cryoglobulins
2.
EMHJ-Eastern Mediterranean Health Journal. 2007; 13 (6): 1438-1448
in English | IMEMR | ID: emr-157125

ABSTRACT

An environmental behavioural modification programme was implemented in Alexandria city, Egypt, in order to help street children to change their behaviour, discover their abilities and develop and acquire new skills and knowledge. The programme included camping and field trips, recreational activities and games, role play and theatre, story-telling, life-skill activities, and gardening and animal care. Data were collected from observational sheets of adaptive behaviour and conversation sessions before and after the intervention on a sample of 35 street children aged between 7 and 15 years. The mean scores for each behavioural item and all items together before and after the intervention were significantly improved in a number of areas, except for speech disorders and substance use


Subject(s)
Humans , Male , Homeless Youth , Psychology, Child , Child Behavior , Program Evaluation , Surveys and Questionnaires , Social Environment , Health Education
3.
Benha Medical Journal. 2006; 23 (1): 417-438
in English | IMEMR | ID: emr-150884

ABSTRACT

Hepatitis C virus [HCV] infects more than 170 million people worldwide and around 20% of blood donors are seropositive by ELIZA to HCV Ab in Egypt. Renal manifestations may be the presenting features of chronic HCV infection. This work was carried out on 200 patients with chronic HCV in order to study the relationship between HCV and chronic kidney disease and to stratify HCV patients according to the degree of albuminuria. It showed that screening for protenuria in patients with chronic HCV Is necessary due to high prevalence of renal affection in these patients. Assessment of microalbuminuria should be done in these patients as an early indicator for renal affection. Albumin creatinine ratio [ACR] had a good reliability as a surrogate measure for routine screening of urine albumin excretion. Awareness of chronic kidney disease [CKD] stage in patients with HCV and renal affection help prediction and early management of renal disease. There was a documented link between cryoglobulinumic and non-cryoglobulinumic membrano-proliferative glomerulonephritis and HCV infection


Subject(s)
Humans , Male , Female , Kidney Function Tests , Prevalence , Albuminuria , Hospitals, University , Enzyme-Linked Immunosorbent Assay/statistics & numerical data
4.
Tanta Medical Journal. 1999; 27 (2): 903-922
in English | IMEMR | ID: emr-52920

ABSTRACT

The present study was carried out to study the changes in plasma atrial natriuretic peptide [ANP] in asthmatic children and in cases with chronic obstructive pulmonary disease [COPD] and to correlate these changes with the ventilatory and cardiac functions in the COPD group. About 105 subjects were selected from Pediatric and Chest Departments, Benha University Hospital. They were classified into 20 asthmatic children [Group A[1]], who were reinvestigated 4 weeks after treatment [Group A[2]]. Their age ranged from 1.5 to 11 years old. This group of patients was compared with 15 healthy children matched for the same ages and sex. Another 60 patients with COPD were subclassified into 3 subgroups. Subgroup I: included 20 cases on hospital admission with acute infective exacerbation [subgroup la], those cases were reinvestigated 6 weeks after medical treatment [subgroup Ib]. Subgroup II included 20 patients with COPD cor-pulmonale and right-sided heart failure. Subgroup III: included 20 patients with COPD without cor-pulmonale. Their age ranged from 40 to 74 years old. This group of patients were compared with 10 healthy subjects matched for the same ages and sex. For all groups, plasma ANP was done while ventilatory functions and echocardiography was done for COPD group only. The main results of this study, showed that plasma ANP was significantly elevated in asthmatic children compared with the control group but, it was significantly higher in subgroups A[1] in comparison to subgroup A[2]. In the COPD group, ANP was significantly elevated in all subgroups. The highest level in subgroup la, the lowest level was in subgroup III. ANP was significantly elevated in subgroup II in comparison to Ib and III subgroups. Also, ANP was correlated with mean pulmonary artery pressure [PAP], surface area of right atrium [RASA], right atrial diameter [RAD], right ventricular diameter [RVD] and right ventricular anterior wall [RVAW] diameter. The decrease of ANP in subgroup Ib was associated with improvement in the ventilatory and cardiac functions. We could conclude that; ANP was elevated and correlated with the severity of the disease in both asthmatic and COPD cases. Also, it was correlated with the degree of PAP, right atrial and right ventricular dimensions. So, ANP may give a new meaning in the future for the treatment of both asthmatic and COPD cases


Subject(s)
Humans , Male , Female , Pulmonary Disease, Chronic Obstructive , Atrial Natriuretic Factor/blood , Lung Diseases, Obstructive
5.
Benha Medical Journal. 1999; 16 (3 part 2): 829-842
in English | IMEMR | ID: emr-111753

ABSTRACT

Radio contrast media [RCM] induced nephropathy has been defined as an acute impairment of renal function following exposure to radiographic contrast materials after excluding other causes of renal impairment [Bersketh and Kjellstrand, 1984]. The aim of the present work is early detection of asymptomatic radio-contrast media associated nephrnpathy and its possible effect on glomerular-and tubular functions. The study included 35 subjects divided into two groups: Group I: 20 patients received RCM urographin l ml/kg body weight and Group II: 15 healthy persons as normal control who received normal saline as a placebo. Both groups were subjected to thorough clinical examination and the following laboratory investigations: urinary microalbuminuria before as well as 24 hours after RCM to test glomerular function urinary alkaline phosphatase before RCM administration as well as 5 hours. 24 hours as well as 5 days after as a test for tubular function. The results of the present study showed significant increase in microalbuminuria in group I patients after administration of RCM, also there was statistically significant increase in the mean values of urinary alkaline phosphatase observed 5 hours. 24 hours, and 5 days after RCM


Subject(s)
Humans , Male , Female , Kidney/toxicity , Kidney Function Tests , Urography
6.
Benha Medical Journal. 1998; 15 (2): 431-444
in English | IMEMR | ID: emr-47696

ABSTRACT

This study was done to evaluate the plasma endogenous antioxidant enzymes activity [glutathione peroxidase, catalase and superoxide dismutase] in patients with end stage renal disease. Sixty patients were studied. They were divided into two groups: group I [30 patients with chronic renal failure on maintenance hemodialysis] and group II [30 patients with different degrees of renal impairment on conservative drug managemen]. Thirty healthy volunteers with normal kidney function were taken as a control group [group III]. For all of them the following was done: full medical history, complete clinical examination, hemoglobin concentration and hematocrit value, serum urea, creatinine, uric acid, calcium, phosphorus, fasting and 2 hours postpr and ial blood sugar, creatinine clearance, and blood levels of super-oxide dismutase, glutathione peroxidase and catalase. We found that the blood level of superoixde dismutase was significantly lower in group I than group III [P. < 0.0001] and it was significantly lower in group II than group III [P < 0.0001] and there was no significant difference between group I and group II [P < 0.3720]. The blood level of glutathione peroxidase was significantly lower in group I than group III [P < 0.0001] it was significantly lower in group II than group III [P < 0.0001] and significantly lower in group I than group II [P < 0.0117]. The plasma level of catalase was significantly lower in group I than group III [P < 0.001] and it was significantly lower in group II than group III [P < 0.0165] and there was no significant difference between group I and group II [P < 0.7002]. There was positive correlation between hemoglobin concentration and whole blood superoxide dismutase [r= 0.5767-P<0.0001] and also plasma catalase [r=0.2348 P<0.05]. It can be concluded that impaired activity of endogenous antioxidant enzymes occurs early in the course of chronic renal failure and is further exacerbated by hemodialysis resulting in permenant oxidative stress that can be an important mediator contributing to the progression of renal failure and to associated complications such as anemia consequently, it may be possible to propose that some antioxidant substances may be useful for such patients


Subject(s)
Humans , Male , Female , Antioxidants , Superoxide Dismutase , Kidney Function Tests , Renal Dialysis
7.
Benha Medical Journal. 1998; 15 (3): 191-204
in English | IMEMR | ID: emr-47729

ABSTRACT

This study was carried out in Benha University hospital on 20 patients with liver cirrhosis [Group I], 25 patients with chronic hepatitis [Group II] and 20 healthy controls. Thorough history and clinical examination was done to all subjects. Abdominal ultrasonography and the following laboratory investigations were performed to every subject: AST, ALT, serum albumin, serum bilirubin, Prothrombin time [PT], HCV Ab, HBs Ag, HBc Ab [IgG]. HBe Ab and serum level of intercellular adhesion molecule- 1 "sICAM- 1". Liver biopsy was done to patients only. Assessment of disease severity was judged by Child-Pugh classification. Assessment of disease activity was done by histopathological staging and by ALT and AST levels. Our work showed that serum level of sICAM- 1 was significantly high in both patient groups compared to controls, and this elevation was attributed to both increased hepatic production and defective hepatic clearance. The serum level of sICAM-1 correlated significantly with both disease severity and activity. Our study showed that serum level of sICAM-1 can be used as a screening non-invasive test with high specificity [100%] and sensitivity [94.6%] to detect patients with chronic liver diseases. On the other hand we failed to find a significant difference in the serum level of sICAM-1 between the two patient groups. Therefore, serum level of sICAM-1 has a poor diagnostic value with low specificity [78.6%] and sensitivity [43.5%] to differentiate patients with chronic hepatitis from patients with cirrhosis


Subject(s)
Humans , Male , Female , Hepatitis, Chronic , Intercellular Adhesion Molecule-1 , Liver Function Tests , Biopsy/pathology , Histology , Hepatitis C Antibodies , Hepatitis B Surface Antigens , Serum Albumin , Bilirubin/blood , Prothrombin Time
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