ABSTRACT
Background: radio frequency wave [RFW] generated by mobile phones and wireless communication systems has been reported to cause adverse effects on reproductive function, vision and hematological parameters, possibly through oxidative stress. The aim of this study was to evaluate the effect of RFW generated by base transceiver station BTS on oxidative stress in testis, eye and erythrocyte, and the prophylactic effect of vitamin E by measuring the antioxidant enzymes activity, including: glutathione peroxidase [GPx], superoxide dismutase [SOD] and catalase [CAT], and lipid proxidation
Materials and Methods: thirty-two adult male Sprague-Dawley rats were randomly divided into four groups and treated daily for 45 days as follows: control, treatment control [vitamin E 200 mg/kg of body weight/ day by gavage], sham exposed group [exposed to 900 MHz RFW], and treatment group [received vitamin E and exposed to RFW]. Control and treatment control groups were not exposed and were only given the vehicle, i.e., distilled water. On the last day of the study, all the rats were sacrificed and their testes, eyes and erythrocyte were collected and used for measurement of antioxidant enzymes activity and lipid peroxidation
Results: exposure to RFW in the sham exposed group decreased antioxidant enzymes activity and increased lipid peroxidation compared to both control groups [p<0.05]. In the treatment group, vitamin E improved antioxidant enzymes activity and reduced lipid peroxidation compared to the sham exposed group [p<0.05]
Conclusion: RFW causes oxidative stress in eye, testis and erythrocytes and vitamin E improved oxidative stress in these tissues
ABSTRACT
Background: exposure to electromagnetic radiation may impair memory. This study was conducted to evaluate the effect of radiofrequency wave [hereafter referred to as RFW] on passive avoidance learning and memory in healthy males and females
Materials and Methods: ten adult male and ten female Sprague- Dawley rats [230 +/- 20 gr] were randomly divided into four groups including two control groups [one for males and one for females], and two experimental groups [exposed to 900 MHz radio frequency wave] each representing one gender. The exposure was performed for 30 consecutive days [4h/day]. Evaluation of learning and memory of the rats started on the last day of exposure by shuttle box. Learning and memory of animals was recorded by the period of time they remained within the light area; this time was called the light time
Results: results of the study showed that exposure to RFW significantly decreased the duration of light time in the rats within the experimental groups as compared to the control groups [P<0.05]. Exposure to RFW significantly decreased the light time in females in comparison to males in the experimental group [P<0.05]. Histological study of brain section did not show significant changes between Groups
Conclusion: with regard to these findings, it was concluded that exposure to RFW causes disorder in memory retention of passive avoidance learning in rats. The extent of damage to the learning and memory in rats exposed to RFW was more for females than males
ABSTRACT
In pregnant mothers, maternal diabetes occurs when pancreas can't produce enough insulin resulting in increased blood glucose levels in the mother and subsequently in the fetus. This investigation was conducted to evaluate the effects of maternal diabetes on cerebellum of offspring of diabetic mothers [ODM], which was carried out at the veterinary faculty of Shiraz University in 2007-2008. This was an experimental study that included sixteen normal adult female rats divided in two groups. Diabetes was induced in one group by Alloxan agent. Both groups became pregnant by natural mating. At 7, 14, 21 and 28 days after birth, the cerebellum of all offspirings were collected and the weight of neonates was also measured. After producing histological slides, Olympus BX51 microscope and Olysia software were used. Various histological parameters used included gray and white matters thicknesses [micro], the number of cells in gray and white matter separately per unit [mm[2]] and the ratio of gray matter to white matter. Cerebellar parameters decreased in ODM as compared to the control group. The body weight of ODM was significantly more than that of the control group [p<0.05]. Maternal hyperglycaemia exhibited deleterious effects on cerebellum during fetal life, which remained persistent during postneonatal period. Maternal diabetes also resulted in reduction of number of cells and thicknesses of both gray and white matter