Influence of Environmentally Synthesized Silver Nanoparticles on Seed Quality Traits in Groundnut

Silver nanoparticle (AgNPs) is one of the widely used nanoparticles because of their antimicrobial properties. In this present study, the effect of green synthesized silver nanoparticles and bulk form of silver (AgNO3) at different concentrations (250, 500, 750 and 1000 ppm) on seed quality parameters of groundnut were studied. Silver nanoparticles synthesized using Azadirachta indica leaves were characterized by Dynamic light scattering, UV- Vis and FTIR spectrum. Size, zeta potential, UV- Vis absorbance peak and FTIR spectrum of the AgNPs measured 28.6 nm, 24.6 mV, 350 to 490 nm and 3334.53 cm-1 respectively. The results showed that AgNPs 1000 ppm was found best in enhancing the seed quality parameters such as germination percentage, root length, shoot length, seedling length, root dry weight, shoot dry weight, seedling dry weight, seed vigour index I& II.

Design, synthesis, characterization and in vitro evaluation of some novel thiol-substituted 1,3,4-oxadiazoles as GlmS inhibitors

The development of novel medications with previously unidentified action mechanisms is required due to the increasing in antibiotic resistance amongst dangerous microbes. The major goal of the research was to develop in silico and in vitro antibacterial methods for designing an active thiol substituted oxadiazole inhibitor targeting gram-negative and gram-positive bacteria's GlmS receptor. 1,3,4-Oxadiazole was proposed as a scaffold, and the possibility of its synthesis was examined. The least amount of free energy in the ligand configurations was chosen. Analyses of the novel molecules' characteristics were done using ADMET studies. There were four distinct reactions used in the synthesis processes. As the first reagent, substituted carboxylic acids were utilized. Synthesized compounds were characterized by spectral studies and minimum inhibitory concentration was evaluated by in vitro antibacterial examinations of synthesized compounds. Ciprofloxacin served as the study's reference drug. Based on in vitro studies and in silico molecular docking, ROS1-4 established strong binding energy, while ROS3 revealed significant antibacterial activity. These findings support the hypothesis that the proposed scaffold significantly inhibits the GlmS receptor protein.

Production Of Lignocelluloses From Aspergillus Niger Using Areca Nut Spade As Biomass

Areca palm (ChrysalidoCarpus lutescenes) a widely used plant having feathery arching brands with 100 leaflets. All these plants produce much of waste in additions to greeny and nuts. This waste of spade is used for the production of various molecules that are used in industry and pharma sector. Fermentation techniques are used to generate economically important enzymes for industrial and pharmaceutical purposes. Cellulase enzyme degrades the cellulose in between β-1, 4 glucosidic link found in lignocellulosic complex which under physical treatment is slower to degrade. The present study of Aspergillus niger for cellulose production was carried in solid state (SS) and submerged (SM) fermentations for production of cellulase enzyme. Cellulase production in SSF after 72 h of fermentation was 8.02 and in SMF activity was 2.98 per ml of cultured broth at H 6 and temperature at 30°C. Both SMF and SSF were supplemented with lactose and lactobionic acid, which acted as cellulase P production inducers. The aim of the present work was to study the effect of Areca palm spade as substrate for Aspergillus niger and its cellulase production under SMF and SSF.