ABSTRACT
The increasing use of nuclear radiation for human welfare necessitates the search for new, safe, cost effective radio protectors not only for the personnel's charged with the responsibility of working or testing with radiations in laboratories, but also for general public. With this view the present study has been undertaken to determine the deleterious effects of sub lethal gamma radiation on testes and its modulation by Prunus domestica extract [PDE]. For this purpose Swiss albino mice were divided into five groups: [1] Control [2] PDE treated [400 mg kg?1 day?1 for 15 days] [3] Irradiated [5 Gy] [4] PDE + Irradiated and [5] Irradiated+PDE treated. Antioxidant and biochemical assays as well as histopathological analysis were performed to verify PDE radioprotective potential. Radiation induced histological lesions in testicular architecture were observed more severe in all experimental groups. PDE administration before irradiation significantly ameliorated radiation induced elevation in lipid peroxidation and deficit in glutathione, protein, superoxide dismutase, catalase concentration in testes. PDE was found to have strong radical scavenging activity in 2,2- diphenyl-1-picrylhydrazyl [DPPH*] and also showed in vitro radioprotective activity. The results indicate the radioprotective potential of Prunus domestica fruit extract in testicular constituents against gamma irradiation in mice
ABSTRACT
Objectives: To emphasize certain technical points which help in preventing meatal problems when using the Snodgrass repair for the treatment of hypospadias
Patients and Methods: From April 2000 to June 2003, 23 patients underwent Snodgrass repair for hypospadias. The following technical points were adhered to when reconstructing the meatus: [1] Tubularization of the urethral plate was done only up to the midglans. [2] The edges of the neomeatus were sutured to the edges of the glans wings. [3] The urethral stent used was at least 2 Fr. smaller than the size of the neourethra. [4] A stitch was taken on the dorsal aspect of the glans to hold the stent in place and to prevent it from exerting pressure on the suture line of the approximated glans edges
Results In all patients a normally slit glans was obtained. No meatal stenosis was seen in any of the patients with an average follow up of six months
Conclusion: The technical aspects mentioned help in obtaining a normally slit meatus with very little risk of meatal stenosis
ABSTRACT
Objective: To evaluate the safety and efficacy of povidone iodine with contrast agent as a sclerosant for the endoscopic treatment of chyluria
Patients and Methods: From December 1999 to October 2003, a total of 22 patients having chyluria were treated. After their baseline evaluation they were subjected to endoscopic instillation therapy. The sclerosing agent was prepared by using povidone iodine with contrast agent diluted with sterile water in the ratio of 1 :1 :3. The side with chylous efflux was identified via cystoscopy. Using a bulb tip ureteric catheter the sclerosing solution was instilled in the pelvicalyceal system. Unilateral instillation was performed in 13 cases; eight on the left and five on the right side. In the remaining nine cases that had bilateral chylous efflux instillation was performed on both sides in the same session. Fluoroscopy was used to see the complete filling of the pelvicalyceal system. The sclerosing solution was kept in the system for five minutes and the ureteric catheter was then withdrawn
Results: All patients were cured from chyluria in the immediate post operative period. Relapse occurred in three patients, but retreatment by instillation therapy resulted in cessation of chyluria also in these cases. The longest follow up was three years, the shortest two months. Fifteen patients were lost to follow up after nine months. None of the cases but the three mentioned previously had relapse during the follow-up period
Conclusion: Povidone iodine is a very safe and efficacious agent for the endoscopic treatment of chyluria by instillation therapy. Using a contrast agent along with it helps to know, under fluoroscopic guidance, the exact amount of sclerosing agent to be instilled to completely fill the pelvicalyceal system. Thus overfilling of the system is avoided and the complications occurring due to pyelointerstitial backflow of the sclerosant are prevented
ABSTRACT
We report a 43-year-old man with a 20 x 20 cm hydatid cyst, spontaneously extruded out from the left lobe of the liver. This complication of hydatid cyst has not been recorded earlier, and makes the case unique in itself and worth reporting. The patient presented with a rare complication of biliary peritonitis of hydatid disease