ABSTRACT
Background and Purpose: Cytokines are among the many immune system factors involved in diabetes pathogenesis. The level of cytokines expression such as IFN- delta is varying in individuals and societies. Due to the fact that diabetes nephropathies are known as inflammatory disorders and the role of cytokines especially IFN- delta in the establishment of inflammations is well understood, the present study was aimed to examine serum level of IFN-delta in type 2 diabetes patients with nephropathy complications
Material and methods: In this cross sectional descriptive study, serum samples were obtained from 100 type 2 diabetes patients with nephropathy and 100 healthy controls for the analysis of IFN- delta serum level [eBiosense, ESP]. Consent forms were also filled out by patients and healthy controls according to the rules and regulations of Zahedan Islamic Azad University Ethical Committee. The obtained data and questionnaires were analyzed in SPSS using ANOVA; p<0.05 was considered as significant
Results: The mean serum level of IFN- delta was 16.09 +/- 7.74 pg/ml and 4.03 +/- 2.00 pg/ml in nephropathic patients and healthy controls, respectively. Statistical analysis of the data showed that the difference in the IFN- delta level was not significant in nephropathic patients and controls
Conclusion: Based on the non-significant differences between the two groups, it seems that there is no association between the level of serum IFN- delta and nephropathy in type 2 diabetics