[Contributions of dysfunctional attitude scale and general health subscales to prediction and odds ratio of depression]

Dysfunctional attitude may be predispose factor for depression, but there are few investigations for that. The aim of this study was to determine contributions of dysfunctional attitude and general health index based on GHQ-28 to depression. In this description and analytical study, a total of 65 patients with major depression and dythymic disorder from Noor and Navab-Safavi psychiatry clinics and 65 healthy individuals with age and sex, and education matched were randomly selected. Dysfunctional attitude scale and general health questionnaire were filled in by two groups. Data were analyzed using linear and logistic regression and correlation methods. Logistic regression analysis on categorized scores of DAS- 26 as high and low risk revealed that odds ration for high risk group was 6.89 fold than low risk one [OR=6.82, Cl/95, 2.9-16.06]. Two point serial correlation between DAS-26 and psychiatrist diagnosis was 0.44. Also, major depression and dysthymic disorder was significantly predicted by general health subscales [P<0.001]. Dysfunctional attitude may be a predisposing risk factor of depression. Predict depression support and Beck's cognitive diathesis stress theory of depression that dysfunctional attitude [26 options] can be used for determination of depression in this group

Valproate-risperidone versus valproate-lithium combination in acute mania

We evaluated the efficacy of valproate plus risperidone versus valproate plus lithium combination in the treatment of acute mania. In 2-week, randomized, double-blind, parallel group study, 46 acute manic patients according to DSM-IV criteria were randomly assigned to receive combination of valproate 20 mg/ kg/day plus risperidone 2-4 mg/day [n=23] or lithium600-1200 mg/day [n=23]. The assessment of efficacy measures were according to Young Mania Rating Scale [YMRS] and Clinical Global Impressions-Severity [CGI-S] and Improvement [CGI-I] scale. Other effectiveness measures included YMRS response [YMRS reduction >50%] and YMRS remission [YMRS total scores

Survey of the prevalence rate of behavioral disorders among thalassemic patients in Isfahan

Chronic diseases have been identified as predisposing factors in behavioral disorders and the prevalence of these disorders is known to be higher in patients than in control groups. Thalassemia too, plays an effective role in increasing the prevalence of behavioral disorders.In order to recognize the prevalence of behavioral disorders in thalassemic patients, a study was performed on 257 patients [144 boys and 113 girls]. A control group was considered for comparison, the members of which were chosen from healthy sisters and brothers of the patients, otherwise from their first class family members, and ultimately from their neighbours. The diagnosis of behavioral disorders was based on DSM-III-R and the required information was collected by questionnaires that were filled in by the parents and by interviewing the patients themselves. The following results were obtained in the final inspection: 1] the prevalence of separation anxiety [P = 0.000], enuresis [P =o 0.021] and depression [P = 0.002] was higher in thalassemic patients, and 2] other disorders under study [oppositional disorders, attention deficit disorder with hyperactivity, conduct disorder, avoidance disorder, over-anxious disorder, pica, encopresis, stuttering, elective mutism and stereotyped-habitual behaviors] did not show a significant difference regarding a P-value above 0.05