ABSTRACT
Impaired glucose tolerance may be defined as intermediate group of individuals whose carbohydrate metabolism does not constitute diabetes but is not entirely normal. It carries a higher risk of developing microvascular disease and a significant percentage of these patients eventually become diabetics. Of the study was to estimate the frequency of gestational diabetes mellitus [GDM] and impaired glucose tolerance [IGT] in urban Sudanese pregnant women in the third trimester. The study also showed the effect of age and parity on IGT. The study was carried out on hundred pregnant women in the third trimester. The frequency of gestational diabetes was 2% and it was 6% for the IGT incidence whereas, 92% of the pregnant women revealed normal fasting plasma levels. The IGT pregnant women were older than the control pregnant women but, the age difference was not significant [28.7 +/- 5.5 years [mean +/- S.D] vs. 27.3 +/- 4.8 respectively, p>0.05]. Also, the IGT pregnant women were found to have mean parity significantly greater than that of the control group [6.7 +/- 2 [mean +/- S.D.] vs. 3.9 +/- 2.1 respectively, p<0.001]. The frequency of GDM and IGT in Sudanese pregnant women is within the universal estimates and parity is an important risk factor that affects impaired glucose tolerance incidence in pregnancy
ABSTRACT
Plots of velocity against substrate concentration for the metabolism of oestradiol by liver microsomal preparation displayed multiphasic behavior. Computer analysis of this multiphasic plot suggested an initial rectangular hyperbola [i.e. typical Michaelis Menten Kinetics], followed at higher substrate concentration by the appearance of a sigmoid curve. It is concluded that oestradiol - 17 B is either metabolized by two independent enzymes with different Km values or by a single enzyme with more than one substrate binding site which interact in a cooperative manner