ABSTRACT
Herbal medicine is plant derived material or preparations with therapeutic or other human health benefits, which contain either raw or processed ingredients from one or more plants. Allopathic medicine are said to be more successful in acute conditions of diseases, but due to its side effects plant based medicines are preferred. In the end of 18th century herbal medicines started popularizing in healthcare area. The utilization of medicinal herbs became 60% in most of the countries and 70 -80% of Chiniese, Indian, African and Germany people used from 19th century up to now. Some of the medicinal plants have higest trade in world herb market consistently through past years. These plants are Panax ginseng, Sylibum marianum, Zingiber officinalis, Allium sativum, Glycyrrhiza glabra, Ginkgo biloba, Echinicea indica, Rodeala rosea, Hypericum perforatum and Curcuma longa have shown highest trade in world herb market and these are the top plants which are used in the herbal preparation.
ABSTRACT
A new absorption ratio method was developed and validated for the determination of valsartan and hydrochlorothiazide in tablets. Calibration curves for valsartan and hydrochlorothiazide over concentration range of 2-20 μg/ml were plotted and molar absorptivity for both the drugs were calculated at both the wavelengths of 270.5 nm (l-max of hydrochlorothiazide) and 231.5 nm (iso- absorptive point). The results of analysis have been validated statistically and by recovery studies. The value of standard deviation was satisfactory and recovery studies ranging from 99.05-102.23% for valsartan and 97.42-100.22% for hydrochlorothiazide were indicative of the accuracy and precision of the proposed method. The results of the assay are in good agreement with the label amount. The method was found to be simple, rapid, and accurate and can be adopted in routine analysis of these drugs in formulations. Due to these attributes, the proposed method could be used for routine analysis of these drugs in combined dosage forms.