ABSTRACT
Lingual thyroid is a rare developmental abnormality characterized by the failure of the thyroid gland, or remnants, to descend from anywhere along its embryologic path of origin at the foramen caecum to its normal eutopic pretracheal position. The reported prevalence of lingual thyroid is 1 in 100,000, and it is more common in females, with a female to male ratio ranging from 3:1 to 7:1. Carcinoma of the lingual thyroid is even more unusual with less than 1% of lingual thyroids undergoing malignant transformation. Only 40 cases have been reported in the world literature. Herein, we present an uncommon case of papillary carcinoma of lingual thyroid with bilateral cervical nodal metastases in an elderly female with the absence of an orthotopic thyroid gland. Ours is an unusual case report analyzing the diagnostic and therapeutic issues, surgical management strategies and treatment outcomes related to this rare disease entity
ABSTRACT
Total pancreatic lipomatosis is an unusual entity of pathologic significance and speculative origin. It refers to complete replacement of pancreatic parenchyma by fat cells. Fat replacement may vary from mild fatty infiltration to massive replacement of the pancreas by adipose tissue, resulting in malabsorption syndrome due to pancreatic insufficiency. We present the case of a 60-year-old elderly woman with atypical abdominal complaints, diabetes mellitus, weight loss and steatorrhea. Abdominal computed tomograms were diagnostic of pancreatic lipomatosis. Magnetic resonance [MR] imaging verified this impression. The patient improved clinically after an 8-week trial of high-dose oral pancreatic enzyme replacement therapy. There is a marked reduction of steatorrhea and weight gain. This case report focuses on pathophysiology, diagnosis and treatment guidelines of pancreatic lipomatosis