ABSTRACT
Introduction: Several parameters are used for the estimation of gestational age by ultrasonography. Measurementand demonstration of fetal cerebellum is a new and unique parameter of fetal brain growth and also useful forassessment of gestational age. The cerebellum is part of hindbrain and lies in posterior cranial fossa. In theembryo it appears at the end of 5th week of intrauterine life.Aim: 1. To measure and correlate transvrerse cerebellar diameter (TCD) with fetal gestational age (GA) and deriveregression equation. 2. To evaluate cerebellar growth pattern by ultrasonographic cerebellar grading.Material and Methods: This prospective study was carried out on 100 pregnant women between12-40 weeks ofpregnancy attending the R.C.S.M. Govt. Medical College Kolhapur for routine ultrasound examination,Transversecerebellar diameter was measured and cereballar grading was done by ultrasongraphically.Results: We observed a linear correlation between TCD and GA (correlation coefficients-r=0.995, p=0.000 ) Fetalcerebella were found to be 61,15 and 24% cases as grade I,II and III respectively.The grade changed from I to IIIwith advancing gestational age. The median gestational age and TCD were 18.42 weeks and 1.9cm for grade I,and 28.42 weeks and 3.3cm for grade II and 35.99 weeks and 4.2cm for grade III.Conclusion: Regression analysis indicated a strong relationship between TCD and gestational age indicating TCDcan be used as reliable parameter for estimation of gestational age.Its grading can be used in evaluation ofdevelopment of fetus.
ABSTRACT
ABSTRACT The present research work was envisaged to develop bilayer tablets to improve therapeutic efficacy of antibiotic combination for the treatment of sexually transmitted diseases. The combination of two antibiotics i.e. cefixime trihydrate and ofloxacin were used for the preparation of bilayer tablets which act against genito-urinary infections. The formulations comprise of cefixime trihydrate as immediate release layer formulated using different superdisintegrants and ofloxacin as extended release layer containing HPMC K100M. Evaluation of bilayer tablets were performed for the immediate release cefixime layer and sustain release ofloxacin layer with optimization of excipients. The immediate release layer of cefixime showed complete release within 30 min and ofloxacin release was extended up to 24 hours. The similarity factor value of ofloxacin sustained release layer was found to be 87.01 for initial and 80.35 after 3 months stability when compared with marketed reference product. The present study revealed that cefixime trihydrate and ofloxacin bilayer tablets were successfully developed for the use against sexually transmitted infections.