ABSTRACT
Background & Objectives: Out of total 328 antigens recognized by the International Society of Blood Transfusion (ISBT), ABO and RhD antigens are the most important from the transfusion medicine perspective. The present study was conducted with larger sample size than prior studies to determine frequencies of ABO and Rh alleles and obtain distribution of ABO and RhD blood group pattern among blood donors. Methods: A retrospective study was conducted in the Department of IHBT, Civil Hospital, Ahmedabad from October 2007 to September 2012. ABO grouping and RhD typing was done using conventional tube technique on a total of 109771 donors. Commercial anti-sera and in-house prepared cells were used for cell and serum grouping respectively in those tests. Departmental Standard Operating Procedures (SOPs) were followed for each aspect of testing. Observed ABO and RhD antigen frequencies were noted. Bernstein and Hardy-Weinberg equations were applied to determine the allele frequencies of ABO and RhD respectively. Results: Blood group B has the highest prevalence (35.81%) in the population under study followed by O (32.74%), A (22.68%) and AB (8.77%). Female donors comprised only 1.75% of the sample size. Rh D positivity was noted in 94.48% donors. Conclusion: Results obtained were quite similar to prior studies from Ahmedabad with smaller sample size. Remarkable differences were noted as compared with western population. The data generated in the present study combined with several other studies of different geographical region of India has significant implications in inventory management of blood transfusion services.
ABSTRACT
Background & objectives: Blood is lifesaving fluid that cannot be created artificially. So, Blood donors are the precious resources. Whole blood donation is generally considered to be a safe procedure but sometimes adverse donor reaction (ADR) may occur. Recognition and evaluation of the so called adverse donor reactions during and after whole blood donation has a great value for improving the supply of the blood donation. The present prospective study was carried out with an aim to estimate the frequency and severity of adverse events occurring in whole blood donors at our Regional Blood Transfusion Centre and to study the effect of entertainment as an anxiolytic on development of ADR. Material and Method:The present prospective study was carried out at the IHBT Department of B.J. Medical College, Civil Hospital Campus, Ahmedabad. The period of the study was 2 years ranging from 1st September, 2009 to 31st October, 2011. A total of 42,684 whole blood donations were accepted during the period either on replacement basis in house in blood bank or on voluntary basis in outdoor blood donation camps. On 22-02-2011 television set with entertaining channels was installed at the donor reception area and phlebotomy room of the blood bank. Result:It was noted that 632 (1.48 %) donors had developed one of ADR. Conclusion: Because of anxiety syndrome, the rate of ADR was very high in first-time donors (3.25 %) as compared to repeat donors. Television set with entertaining channels had anxiolytic effect on the donors and striking decline (0.81 % to 0.45 %) was noted in the adverse reactions in replacement donors at blood bank.