Study of using Doppler velocimetry of uterine and ovarian arteries in cases of dysfunctional uterine bleeding

This is a descriptive cross-sectional study of 54 cases with dysfunctional uterine bleeding done at the departments of Ob/Gyne and radiology during the period January 1999 to December 1999. The aim of the study -was to study the accuracy of using Doppler velocimetry study of the uterine and ovarian arteries in correlation to the histopathologic pattern of the endometrium in cases complaining of dysfunctional uterine bleeding in Suez Canal University Hospital. The results of this study indicated that the resistance index of both the uterine and ovarian arteries were significantly lower than normal in cases with dysfunctional uterine bleeding. The Doppler ultrasound can't differentiate between the different types of endometrial patterns in cases with dysfunctional uterine bleeding. The uterine and ovarian arteries flow velocity waveforms have high specificity in detecting the endometrial pattern in cases with dysfunctional uterine bleeding

Comparative study of aromatase inhibitor, letrozole, versus medroxy-progesterone acetate for the treatment of endometrial hyperlasia

This study included 40 women [35 to 40] years of age, all were complaining of irregular uterine bleeding. The women were randomized after counseling into two groups: Groups I [n=20] had given medroxy-progesterone acetate 5 mg twice daily and group II [n=20] had given 2.5 mg letrozole tablets twice daily. The duration needed for the stopping of bleeding, the need for further intervention or treatment were recorded. Moreover, after 3 and 6 months, both groups had another endometrial biopsy re-evaluated. The investigator was blind to the allocation as the drugs were dispersed by the hospital pharmacy in registered code. Medroxy-progesterone was found to be significantly more effective in controlling the uterine bleeding compared to letrozole [mean duration 8.3 in group I versus 12.1 days in group II]. However, letrozole was statistically insignificant in returning the normal endometrial pattern after 3 month treatment compared to medroxy-progesterone. On the other hand, letrozole was statistically significant in returning the normal endometrial pattern after 6 month treatment compared to medroxy-progesterone. Finally, the need for further intervention was less in the letrozole group

Late luteal phase dysphoric disorder: do we need another psychiatric category?

The prevalence rate of the proposed diagnostic category of DSM-III-R "Late Luteal Phase Dysphoric Disorder" [LLPDD] was assessed in a survey in 2272 Egyptian females in Suez Canal Area. 69.6% of the surveyed females reported symptoms and patterns that qualify them to have "Premenstrual Tension Syndrome" [PMS]. However, 703 of those who have the disorder reported that they need treatment for their symptoms. This represents 30.9% of the sample surveyed. These high prevalence rates, the biological necessity of changes, the predominance of pains and physical symptoms, together with the highest need for treatment in married and infertile females suggest that inclusion of the LLPDD in DSM-IV might not be an ideal choice