Evaluation of Podocalyxin level in pre-eclampsia with severe features' patients: a cross-sectional study

Background: This study aims to evaluate the level of podocalyxin (PCX) in preeclampsia with severe features patients and correlate it with the results of laboratory tests.Methods: The current study was a cross-sectional study conducted in Assiut Women Health Hospital between April and October 2018.  The study included 60 patients divided into two groups; Group (A): 30 patients diagnosed to have preeclampsia with severe features and Group (B): 30 patients as normal control group. Complete laboratory investigations with measurements of the PCX level was performed for all study participants.Results: No statistically significant difference between the study group and control group according to blood urea (p= 0.339) and serum creatinine (p= 0.801).There was statistically significant difference between the study group and control group according to PCX level (p= 0.001); the mean PCX was 3340.0 ± 2394.6 in the study group versus 1083.5±1400.2 in the control group. Univariate analysis revealed podocalyxin was not correlated with clinical data or laboratory investigations.Conclusions: Podocalyxin levels were significantly elevated in preeclampsia.

accuracy of FNAC for diagnosis of breast carcinoma in Gezira state, central Sudan

Breast cancer is a leading cause of death in many countries worldwide and breast lesions remain a common diagnostic dilemma. Fine-needle aspiration cytology [FNAC] has been suggested as the most important, first line, minimally invasive procedure in the management of patients with breast lesions. The aim of this study is to assess the diagnostic efficacy of breast FNAC in patients with breast lesions compared with that of the definitive histological diagnosis. This is a hospital-based retrospective study of 112 breast FNAC samples were carried out at Cancer Institute in Medani Gezira state. FNAC findings were correlated with data from histopathology records to determine the sensitivity and specificity of FNAC. Age group of the patients ranged from 26 to 80 years with mean of 42 years. Among the study subjects [112 case], ductal carcinoma is the common hitological linding 83/88 [94%]. According to the cytology, 79% were malignant, 4% were benign and 2% were suspicious. Histological correlation was done in 68 cases. The overall diagnostic accuracy of FNAC was 92.3%, with sensitivity and specificity of 89.2% and 66.5% respectively. FNAC of breast is asimple, cost effective and less traumatic method for diagnosing breast cancer. It is highly sensitive and accurate, and can reduce the needs for open biopsies. It is recommended that FNAC should be used as a first line method for determining the nature of breast lumps

Quality of life of Sudanese patients with benigan prostatic hyperplasia. The oblivious problem

Although the IPSS and QOL index are universally used, they can only quantify the severity of lower urinary tract symptoms suggestive of benign prostate hyperplasia [BPH] and evaluate treatment efficacy, but cannot fully reflect the overall quality of life. Moreover, because QOL scale depends on the culture background, it is necessary to develop a Sudanese version of the scale. To evaluate the impact of BPH on the quality of life by assessing the physical, mental and stress states among patients of BPH. This study was conducted on 424 patients with BPH in Gezira Hospital for Renal Disease and Surgery [GHRDS], Sudan. The study was cross-sectional, prospective small-scale hospital based study using simple random sampling technique. The subjects were limited to the Sudanese patients, who could hear and answer the questions of the questionnaire independently and that was done for accuracy and privacy. Taking the patient's educational level into account, all items were expressed in spoken language. The data collection tool was a questionnaire which was modified to twelve items from the BPH Quality of Life Index. The majority 386 patients, 91% were physically fit. The pattern of urination was bothering to their daily life of around 320 patients/75.5%, 225 patients/53.1% of patients were worried about the outcome of the disease, 259 patients/61.1% were not concerned of having prostate cancer and 332 patients/78.2% were satisfied with their sleep. The sexual life had been affected in 201 patients/47.4%. The physical state was assessed by the ability of the patient to pray Friday Jomaa at the mosque which was 85.8% and also by attending important Sudanese obliging social activities like condolence which was [91.9%] of the patients. The impact of BPH on quality of life was obviously significant in the three domains; physical, mental and stress state among patients of BPH in GHRD and S. There should be a validated scale for the BPH Quality of Life Index addressing the traditional strata for Sudanese patients

Retropublic prostatectomy in 96 patients in Soba university hospital

Retropubic prostatectomy [RPP], is a good treatment option for men with symptomatic bladder outlet obstruction caused by large size prostate. To determine the intraoperative, early and late postoperative complications of retropubic prostatectomy. This is a retrospective, small-scale hospital based study conducted in Soba University Hospital, Sudan. We include 96 patients, from Jan 2003 to Jan 2008 who underwent RPP. The mortality rate was zero. Retrograde ejaculation in 50.1%, clot retention due to catheter block in 36.5% and transient urinary incontinence in 24%, all were improved within the first three months postoperatively and intraoperative bleeding was reported in 9 patients [10%]. Erectile dysfunction in 7.5%, wound infection in 6.3%, urethral stricture in 5.2%, urine leakage in 4.2% and injury to adjacent structures [peritoneum-bowel] was not reported. The complications of retropubic prostatectomy in Soba Hospital was found to be comparable to the literature

Gastrointestinal Basidiobolomycosis mimicking colon cancer in a Sudanese patient

Basidiobolomycosis is a rare disease caused by the fungus Basidiobolus ranarum. The incidence Rate of Gastrointestinal Basidiobolomycosis is approximately 1 in 45,333,334 or 0.00% in every 5 people in USA], member of the class Zygomycetes found worldwide [1].Basidiobolomycosis is usually a subcutaneous infection but rarely gastrointestinal1. This fungus is found mainly in the soil and on decaying vegetations2. It has been isolated from the banks of tropical rivers in West Africa, and has also been found in association with some insects2. The fungus is known to be present in the gastrointestinal tracts of reptiles, amphibians, and some bat species3. Definitive diagnosis requires culture and serological testing may be helpful. The fungal morphology and the Splendore-Hoeppli phenomenon are characteristic histological features. Basidiobolomycosis is treated with surgical resection and itracanzole 200mg BD for three months or Amphotericin B 5mg /kg iv/24 hrs4