ABSTRACT
65 Radical mastectomy specimens were sent to the Pathology Department of Kasr El Einy Hospital and 10 postmortem breast samples were subjected to routine light microscopy, to determine the histological type and the grade of the tumour. This was followed by determining the degree of angiogenesis in the tissues examined using a graduated eye piece [point counting method] and the degrees of neovascularization were divided into minimal < 15 percent of total surface area, moderate 15-55 percent and marked > 55 percent SA. It was apparent from the results that as the tumour grade increased there was a proportionate increase in host tissue neovascularization, it thus may be assumed that the actual degree of neovascularization possibly enhances tumour cell aggressiveness and hence the histological grade increases. Another finding of some importance was that duct carcinomas appeared to be more likely to produce pronounced angiogenic responses in the tissues than lobular types; this may in part explain the more aggressive behaviour of the duct carcinoma group compared to the lobular neoplasms