ABSTRACT
Background: Cardiac autonomic dysfunction (CAD) and neuropathy is common in diabetes mellitus but theabnormalities in Autonomic nervous system (ANS) and the influence of altered glycaemic indices oncardiovascular parameters by using HRV has not been elucidated in prediabetics. Hence, the present studywas aimed to measure HRV and to find out the association, if any, between the parameters of HRV andglycaemic index in Prediabetics.Methods: Recording of short term HRV in thirty prediabetics and thirty apparently healthy controls of eithersex in the age group of 40 to 65 years were done. The subjects were enrolled as per American DiabetesAssociation (ADA) criteria on the basis of their glycaemic indices viz: Fasting blood sugar (FBS), 2h Oralglucose tolerance test (OGTT) and Glycated haemoglobin (HbA1c).Result: Prediabetic subjects showed a significant decrease (p=0.007) in SDNN (Time Domain parameter ofHRV) when compared with the control group, whereas the RMSSD and other frequency domain parametersof HRV did not show any significant difference in the two groups. However, the correlation analysis betweenvarious parameters of HRV and glycaemic indices showed a significant negative association.Conclusion: A significant decrease in SDNN along with significant negative association between HRVparameters and glycaemic indices indicates towards a decrease in parasympathetic activity of cardiacautonomic function and hence the possibility of initiation of CAD in Prediabetic stage itself.
ABSTRACT
Declining hearing sensitivity is appreciated as a normal age related change. However, studies reveal that health variables other than age play significant role in hearing impairment over time. Hypertension is one such variable. The objective of this study was to assess whether the hypertension has an accelerating effect on age related reduction in hearing function in males in the age group of 40-60 years. Systolic and Diastolic blood pressure and Pure Tone thresholds in frequency range 250-8000 Hz were measured in 30 known hypertensive (HT) male subjects in the age group of 40-60 years and 30 age and sex-matched normotensive (NT) controls. There was no significant difference in hearing thresholds at various frequencies between HT and NT group and between uncontrolled HT (n=15) and controlled HT subgroups (n=15). However, a significantly positive correlation between the systolic blood pressure and Air conduction thresholds at 4000 Hz and 8000 Hz and Bone conduction thresholds at 4000 Hz were noted in uncontrolled HT subgroup. Results of the current study demonstrated towards the potentially negative impact of uncontrolled hypertension on the auditory function in the age group of 40-60 years.
ABSTRACT
Now a days as very few drugs are coming out of research and development and already existing drugs are suffering the problem of resistance due to their irrational use specifically in case of drugs like antibiotics. Hence, change in the operation is a suitable and optimized way to make the some drug more effective by slight alteration in the drug delivery.