ABSTRACT
We present a rare case of clear cell adenocarcinoma of the male bulbomembranous urethra. Mostly these tumors have been described in the female urethral tract with its possible origin from mullerian remnants, wolffian remnants or paraurethral glands. Histologically, these tumors have typically tubulocystic pattern comprising of hobnailed cells with clear glycogenated cytoplasm along with well-defined cytoplasmic membranes. This case is being presented due to its rarity, aggressive behavior and to discuss, trauma as its possible etiological factor
Subject(s)
Adenocarcinoma, Clear Cell/diagnosis , Adenocarcinoma, Clear Cell/pathology , Adenocarcinoma, Clear Cell/surgery , Histocytochemistry , Humans , Magnetic Resonance Imaging , Male , Microscopy , Middle Aged , Penis/pathology , Penis/diagnostic imaging , Urethral Neoplasms/diagnosis , Urethral Neoplasms/pathology , Urethral Neoplasms/surgeryABSTRACT
We report a case of 50-year-old male with obstructive jaundice diagnosed as peri-ampullary collision tumor comprising of large cell neuroendocrine carcinoma and signet ring cell carcinoma. The association of neuroendocrine (usually carcinoids) and adenocarcinoma is extremely uncommon with only few case reports available in the reported literature.
Subject(s)
Carcinoma, Neuroendocrine/complications , Carcinoma, Neuroendocrine/diagnosis , Carcinoma, Neuroendocrine/pathology , Carcinoma, Signet Ring Cell/complications , Carcinoma, Signet Ring Cell/diagnosis , Carcinoma, Signet Ring Cell/pathology , Common Bile Duct Neoplasms/diagnosis , Common Bile Duct Neoplasms/pathology , Histocytochemistry , Homeodomain Proteins/analysis , Humans , Immunohistochemistry , Magnetic Resonance Imaging , Male , Microscopy , Middle Aged , Radiography, Abdominal , Synaptophysin/analysis , Trans-Activators/analysisABSTRACT
Context: Monitor 100® (Electa Lab, Italy) is a newly developed automated method for measurement of erythrocyte sedimentation rate (ESR). Aims: The aim of our study was to compare the ESR values by Monitor 100® against the standard Westergren method. Patients and Methods: This cross-sectional study was conducted at a Level I trauma care center on 200 patients. The samples taken were as per the recommendations charted out by International Council for Standardization in Hematology (ICSH) for comparing automated and manual Westergrens method. Statistical Analysis Used: Bland and Altman statistical analysis was applied for evaluating Monitor 100® against the conventional Westergren method. Results: The analysis revealed a low degree of agreement between the manual and automated methods especially for higher ESR values, mean difference -11.2 (95% limits of agreement, -46.3 to 23.9) and mean difference -13.4 (95% limits of agreement-58.9 to 32.1) for 1 and 2 hours, respectively. This discrepancy which is of clinical significance was less evident for ESR values in the normal range <25 mm/hour (-7.7 mean of difference; -18.9 to 3.5 limits of agreement). Conclusions: The fully automated system Monitor 100® for ESR measurement tends to underestimate the manual ESR readings. Hence it is recommended that a correction factor be applied for the range of ESR values while using this equipment. Further studies and validation experiments would be required.