ABSTRACT
Simple, sensitive, specific and economic spectrophotometric method was developed and validated for simultaneous quantitation of Hydrochlorothiazide and Telmisartan in tablet dosage form. New method based on the simultaneous estimation of drugs in a binary mixture without previous separation was developed. In simultaneous equation method, Hydrochlorothiazide and Telmisartan were quantified using their absorptivity values of at selected wavelengths, viz., 273 nm and 295 nm respectively. The accuracy and reproducibility of the proposed method was statistically validated by recovery studies. The simultaneous equation method permits simple, rapid and direct determination of Hydrochlorothiazide and Telmisartan in commercially available tablet dosage form without previous separations and can therefore be used for routine analysis of both drugs in quality control laboratories.