ABSTRACT
A prospective study was begun on the immunopathogenic characteristics of infection with human immunodeficiency virus (HIV) in order to elucidate the natural history of the disease induced by the virus in Venezuela. The results of a study of 240 individuals with variety of clinical manifestations are presented. The most important findings were depletion of the CD3+, CD4+ subpopulation in most individuals studied, including asymptomatic carriers; significant reduction of the large granular lymphocyte (CD3-, CD16+) pool in AIDS cases; decrease in cytotoxic activity in relation to the viral infection, along with an increase induced by recombinant interleukin 2; and reduction of the CD4 subpopulation in patients with free serum antigen. It is of utmost importance that ongoing research projects to clarity the immunopathogenic mechanisms of HIV be continued so that the characteristics peculiar to HIV infection may be determined, since they can affect clinical manifestation and the desease's development in the Venezuelan population