Primary plasma cell leukemia- A case report.

Plasma cell leukemia is a rare variant of multiple myeloma and this term is applied when the absolute plasma cell count is greater than 2x10⁹ /L or the relative plasma cell number is greater than 20% of the peripheral white blood cells. PCL may be primary or secondary. A 55 year old male presented to our outpatient department with complaints of lower back pain for four months, low grade fever off and on for two months, generalised weakness and loss of appetite for 20 days without prior history of multiple myeloma. His peripheral blood smear showed 26% plasmacytoid cells and bone marrow revealed predominantly plasma cell population (80%) with binucleate and trinucleate forms. Chemotherapy was started but unfortunately patient had expired. This case is presented due to its rare occurrence, presence of organomegaly and poor outcome.

Pattern of hematological disorders diagnosed through bone marrow examination.

Introduction: Blood disorders are very common among different age groups. They usually range from anemias to advanced hematological malignancies. Material and Methods: The present observational study was conducted in the Department of Pathology, M.L.B. Medical College, Jhansi to find out the incidence of different hematological disorders. marrow examination was done. SPSS software was used for data analysis. Results: Hematological disorders were more common among males (63.55%) and among those aged Bone between 21-30 yrs (27.1%). Anemia was the most common diagnosis in 49 cases (41.52%) followed by leukemia in 16 cases (13.56%). Thirteen cases (11.02%) were diagnosed as malarial parasite positive in bone marrow examination. Conclusion: Bone marrow examination is a useful test in reaching the final diagnosis.

Natural selection among Kinnaura of the Himalayan highland: A comparative analysis with other Indian and Himalayan populations.

The present investigation on fertility and mortality differential among Kinnaura of the Himalayan highland is based on data collected from 160 post-menopausal women belonging to the middle and high altitude region of Kinnaur district of Himachal Pradesh (Indian Himalayas). Selection potential based on differential fertility and mortality was computed for middle-and high-altitude women. Irrespective of the methodology, the total index of selection was found to be highest among middle-altitude women (0.386) as compared with high-altitude (0.370) women, whereas for the total population it is estimated to be 0.384. It was found that the Kinnaura of the Himalayan highland showing moderate index of total selection and relative contribution of the mortality component (Im) to the index of total selection is higher than the corresponding fertility component (If). The analysis of embryonic and post-natal mortality components shows that the post-natal mortality components are higher in comparison with the embryonic mortality components among highlanders and needs special intervention and health care. The present findings are compared with other Indian tribes as well as non-tribes of the Himalayan region and other parts of the country. It reveals that this index among Kinnaura is moderate than the other population groups; among the Himalayan population, the highest was reported for Galong (It = 1.07) of Arunachal, whereas the lowest was reported from Ahom (It = 0.218) of Manipur. The correlation and regression analysis between total index of selection (It) and fertility (If) and mortality (Im) components for pooled data of populations of the Indian Himalayan states show that If and Im account for 21.6 and 29.1% variability, respectively. In Crow's total index of selection (It) along with strong association, which is significant at the 1% level, this indicates that mortality plays a greater role in natural selection in comparison with fertility among populations of the Indian Himalayas.