ABSTRACT
Background:Dementia is defined as acquired global impairment of higher cortical functions including memory, the capacity to solve problems of day to day living, the performance of learned perceptuo-motor skills, all aspects of language and communication and the control of emotional reaction, in the absence of clouding of consciousness. Methods: This study sample consisted of 95 demented patients seen at the Outpatient department of Nepal Medical College Teaching Hospital. Results:comparison between patients with Alzheimer’s and vascular dementia, these being the most frequent etiologies, a significant difference among the groups in relation to gender was detected, whereby the female gender predominated in Alzheimer Dementia, whereas males predominated in Vascular Dementia. Conclusion: clinicians need to be more vigilant to rule out depression, anxiety and dementia in geriatric patients. The increasing trend in the number of geriatric patients with neuropsychiatric disorders warrants a better healthcare and social support.
ABSTRACT
More than 40 million households in India depend at least partially on livestock production. Buffaloes are one of the major milk producers in India. The prolactin receptor (PRLR) gene and peroxisome proliferators activated receptor-γ coactivator 1-alpha (PPARGC1A) gene are reportedly associated with milk protein and milk fat yields in Bos taurus. In this study, we sequenced the PRLR and PPARGC1A genes in the water buffalo Bubalus bubalis. The PRLR and PPARGC1A genes coded for 581 and 819 amino acids, respectively. The B. bubalis PRLR gene differed from the corresponding Bos taurus at 21 positions and four differences with an additional arginine at position 620 in the PPARGC1A gene were found in the amino acid sequence. All of the changes were confirmed by cDNA sequencing. Twelve buffalo-specific single nucleotide polymorphisms (SNPs) were identified in both genes, with five of them being non-synonymous.