Inhibitory effects of some substrate level analogues on salp-activity in B-thalassaemia

Higher levels of SALP-activity was recorded in serum of patients with a-thalassaemia in comparison with normal control Subjects at specific PH and temp. Both kinetic constant, Km and Vmax has been determined. Inhibitory effects of three substrate analogues, L-Phe, Adenosine, and inorganic phosphate were investigated. Types and degree of inhibition were determined together with values of Ki [inhibitory constant] using Dixons plot