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Indian J Physiol Pharmacol ; 1994 Jul; 38(3): 220-2
Article in English | IMSEAR | ID: sea-106760

ABSTRACT

A Leucodelphinidin derivative isolated from the bark of Ficus bengalensis Linn demonstrated hypoglycemic action at a dosage of 250 mg/kg given both in normal and alloxan diabetic rats. It's action is closely similar to that of an effective dose of glibenclamide (2 mg/kg) tested under the same conditions. However, after a glucose load the plant product is only just significantly active but not as effective as the sulphonylurea. The efficacy of the plant product as a hydroglycemic agent adds to its other therapeutic effects, as it belongs to the class of flavonoids.


Subject(s)
Animals , Blood Glucose/drug effects , Diabetes Mellitus, Experimental/drug therapy , Flavonoids/isolation & purification , Glucose Tolerance Test , Glyburide/pharmacology , Hypoglycemia/chemically induced , Plant Extracts/pharmacology , Rats
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