ABSTRACT
Trichomoniasis vaginalis is now an important worldwide health problem. Metronidazole has so far been used in treatment, but the metronidazole-resistant strains and unpleasant adverse effects have been developed. Treatment of patients with metronidazole refractory vaginal trichomoniasis constitutes a major therapeutic challenge and treatment options are extremely limited. The last 7 years have seen over seven times as many publication indexed by Midline dealing with pomegranate [Punica granatum] than in all the years preceding them, because of this, and the virtual explosion of interest in pomegranate as a medicinal and nutritional product that has followed, this work is accordingly launched. Natural plant extract purified from Pomegranate [Roman] was in-vitro investigated for its efficacy against T. vaginalis on Diamond media. Besides, infection women [18/20] who accepted to be treated with P. granatum juice were completely cured and followed-up for two months. The anti-trichomoniasis vaginalis activity of P. granatum extract [in-vitro and in-vivo] gave very promising results