Some parasitic flukes infecting farm animals in Al-Santa center, Gharbia governorate, Egypt

A total of 213 farm animals in the vicinity of Al-Santa Center [73 cattle, 90 buffaloes and 50 sheep] were coprologic examined for natural infection with trematod-parasites. The results showed that cattle were infected with Fasciola sp [21.8%] and Paramphistomum sp. [7.3%], buffaloes were infected with Fasciola sp. [17.7%] and Paramphistomum sp. [10%], while sheep were infected with Fasciola sp. [30%], D. dendriticum [5%] and Paramphistomurn sp. [4%]. The three animal species were treated for paramphistomiasis with a total dose of 1800, 6000 and 7500 mgm of Oleo-resin solution of Commiphora molmol [dose of 6 ml of 10 gm% equal to 2 Mirazid [R] The cure was 100% in sheep 80% in cattle and 44.4% in buffaloes. High dose for both cattle and buffaloes to reach 100% cure rate was not tried

Non - histological assessment of liver fibrosis in HCV infection

In this study, a correlation between some serum markers [alanine aminotransferase/ aspartate aminotransferase [AST/ALT] ratio, level of matrix metalloproteinase 9 [MMP9], level of viremia and HCV serotype] and the severity of liver fibrosis in HCV-infected patients was detected. The study included 72 human cases referred to the Early Cancer Detection Unit for liver biopsy assessment. The severity of liver fibrosis was staged, using the METAVIR scoring system, into four stages. The level of viremia did not differ significantly in the different stages of liver fibrosis. Also, the type of HCV had no effect on the severity of liver fibrosis. However, transaminases ratio differed significantly in the different fibrosis stages. This serum test showed relative high sensitivity and specificity [92.6% and 94.38, respectively] in diagnosing severe fibrosis and cirrhosis. However, the level of MMB was inversely correlated with the fibrosis stages and was found to have 88.9% sensitivity and 88.6% specificity when diagnosing severe fibrosis and cirrhosis. Although, the sensitivity of these serum markers did not reach 100%, yet their use can reduce the number of liver biopsies when diagnosing and treating HCV-infected patients