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1.
Journal of Central South University(Medical Sciences) ; (12): 540-543, 2005.
Article in Chinese | WPRIM | ID: wpr-813510

ABSTRACT

OBJECTIVE@#To analyze the risk factors for metastasis and recurrence of hepatocellular carcinoma (HCC) postoperatively.@*METHODS@#Data of 270 cases of postoperative HCC were analyzed by SPSS software retrospectively.@*RESULTS@#Out of the 270 cases, 162 got follow-up study and 136 showed metastasis and recurrence. Lots of risk factors induced the recurrence of HCC, such as AFP, tumor form, venous blood invasion, HBV infection, resection dimension and perioperative transfusion. There were different risk factors at different stages.@*CONCLUSION@#The early recurrence of HCC may be mediated by macro- or micro-vessel blood invasion and metastasis, the late recurrence by multicentric carcinogenesis or introhepatic cacinoma de novo.


Subject(s)
Adult , Female , Humans , Male , Middle Aged , Carcinoma, Hepatocellular , General Surgery , China , Epidemiology , Follow-Up Studies , Hepatectomy , Liver Neoplasms , General Surgery , Lymphatic Metastasis , Neoplasm Recurrence, Local , Epidemiology , Postoperative Period , Retrospective Studies , Risk Factors
2.
Chinese Journal of Oncology ; (12): 279-282, 2004.
Article in Chinese | WPRIM | ID: wpr-271001

ABSTRACT

<p><b>OBJECTIVE</b>Rho, a ras homologous gene, encodes a group of GTP-binding proteins. Our previous study suggested that one member of the Rho gene family, RhoC, was related to the progression of human hepatocellular carcinoma (HCC). This study is to elucidate correlation of Rho overexpression with invasion and metastasis of HCC.</p><p><b>METHODS</b>The expression level of RhoC mRNA and protein in 25 cases of HCC and adjacent non-cancerous liver tissue was examined by RT-PCR and Western blot. Mutation of RhoC gene was examined by PCR-SSCP.</p><p><b>RESULTS</b>The expression of RhoC mRNA and protein was found in all HCC and adjacent non-cancerous liver tissue. The expression level of RhoC mRNA and protein was significantly higher in tumor tissue than in adjacent non-cancerous liver tissue (1.8 +/- 1.1 vs 1.0 +/- 0.7; 33 992 +/- 10 384 vs 17 342 +/- 9998, P < 0.01). The degree of RhoC overexpression was even more marked in metastatic lesions than in primary tumors (P < 0.01). Overexpression of the rhoC gene was significantly correlated with such clinic-pathological findings as cell differentiation, portal vein invasion, number of primary tumor nodules and metastatic lesions (P < 0.05). Mutation of RhoC gene was found in none of the HCC specimens examined.</p><p><b>CONCLUSION</b>Overexpression of RhoC gene may play an important role in carcinogenesis and progression of HCC.</p>


Subject(s)
Adult , Aged , Female , Humans , Male , Middle Aged , Carcinoma, Hepatocellular , Genetics , Metabolism , Pathology , Cell Differentiation , Gene Expression Regulation, Neoplastic , Liver , Metabolism , Liver Neoplasms , Genetics , Metabolism , Pathology , Neoplasm Invasiveness , Portal Vein , Pathology , RNA, Messenger , Genetics , rho GTP-Binding Proteins , Genetics , rhoC GTP-Binding Protein
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