study of urinary oestrogen glucuronides in spontaneous and induced ovarian cycles

The concentrations of estrone-3-glycuronide [E-1-G], estradiol-17-beta glycuronide [E-2-G] and estradiol-16-alpha glycuronide [E-3-G] in serial samples of early morning urine [EMU] were determined in 15 spontaneous cycles, 10 cycles in women treated with human menopausal gonadotrophins [HMG]. The results showed that there was a defined pattern for all three metabolites similar to the pattern of estradiol in plasma and that their concentrations in stimulated cycles were significantly higher than in spontaneous cycles. It was concluded that the measurement of these metabolites in samples of early morning urine offers simple and practical methods for the biochemical monitoring of folliculogenesis in spontaneous and induced ovarian cycles