Twin pregnancies conceived by In-vitro fertilization compared with normally conceived twin pregnancies: Maternal and neonatal outcome / 대한산부인과학회잡지

OBJECTIVE: To compare the obstetric complications and perinatal outcomes of twin pregnancies conceived by In Vitro Fertilization and Embryo Transfer to twin pregnancies conceived naturally. METHODS: Maternal and neonatal data were reviewed for all twin pregnancies. All twin pregnancies (n=116) were divided into IVF twin pregnancyes group (n=43) and naturally conceived twin pregnancyes (n=72). The obstetric and perinatal outcomes were compared and analysed. Statistical analysis was performed using student's t-test, x2 test, and Fisher exact test. Statistical significance was defined as p<0.05. RESULTS: There were no significant differences in maternal age and gestational age between two groups but nulliparity was higher in IVF-ET twin group than naturally conceived twin group. Also no differences of obstetrics and perinatal outcomes were seen between two groups. CONCLUSION: Although twin pregnancies following IVF-ET are more likely to result in bad prognosis, in this study obstetric and perinatal outcomes are comparable to those of naturally conceived twin pregnancies.

A Clinical Study of Borderline Malignant Tumors of the Ovary / 대한산부인과학회잡지

OBJECTIVE: The purpose of this study was to review the clinical features, treatments and prognosis of the borderline malignant tumors of the ovary. METHODS: Thirty-two patients with borderline malignant tumors of the ovary were admitted, operated and confirmed with postoperative histopathological study at department of obstetrics and gynecology, Yonsei University Wonju Christian Hospital. The data were collected retrospectively and all charts were reviewed. RESULTS: The incidence of borderline malignant ovarian tumor was 19.2% (32/167). Age distribution revealed between 18 and 77 years old, the mean age was 43.1 years old. As for the parity distribution of borderline malignant tumor, nulliparity was most common (43.8%). The most common chief complaint was abdominal distension (34.4%). Histologic subtypes were mucinous in 19 cases (59.4%), serous in 13 cases (40.6%). According to FIGO classification, 28 cases (87.5%) were stage I, 1 case (3.1%) was stage II, 3 cases (9.4%) were stage III. Sixteen cases (50%) underwent conservative surgery (unilateral salpingooophorectomy or cystectomy). Sixteen cases (50%) were treated with total abdominal hysterectomy and bilateral salpingooophorectomy. Fifteen cases (46.9%) received adjuvant postoperative chemotherapy. Excluding 5 cases lost to follow up, patients were alive and were followed from 9 months to 100 months. (mean 36 months).

A Clinical Study of Borderline Malignant Tumors of the Ovary / 대한산부인과학회잡지

OBJECTIVE: The purpose of this study was to review the clinical features, treatments and prognosis of the borderline malignant tumors of the ovary. METHODS: Thirty-two patients with borderline malignant tumors of the ovary were admitted, operated and confirmed with postoperative histopathological study at department of obstetrics and gynecology, Yonsei University Wonju Christian Hospital. The data were collected retrospectively and all charts were reviewed. RESULTS: The incidence of borderline malignant ovarian tumor was 19.2% (32/167). Age distribution revealed between 18 and 77 years old, the mean age was 43.1 years old. As for the parity distribution of borderline malignant tumor, nulliparity was most common (43.8%). The most common chief complaint was abdominal distension (34.4%). Histologic subtypes were mucinous in 19 cases (59.4%), serous in 13 cases (40.6%). According to FIGO classification, 28 cases (87.5%) were stage I, 1 case (3.1%) was stage II, 3 cases (9.4%) were stage III. Sixteen cases (50%) underwent conservative surgery (unilateral salpingooophorectomy or cystectomy). Sixteen cases (50%) were treated with total abdominal hysterectomy and bilateral salpingooophorectomy. Fifteen cases (46.9%) received adjuvant postoperative chemotherapy. Excluding 5 cases lost to follow up, patients were alive and were followed from 9 months to 100 months. (mean 36 months).

The prenatal care and delivery in a pregnant woman complicated by hereditary sideroblastic anemia / 대한산부인과학회잡지

Anemia is the one of the most common complications among pregnant women, but sideroblastic anemia is very rare condition. The sideroblastic anemias have diverse etiologies but have in common an impaired biosynthesis of heme in the erythroid cells of the marrow. The ringed sideroblasts in the bone marrow aspirate is diagnostic hallmark of sideroblastic anemia. We report here a prenatal care and delivery in a pregnant woman complicated by hereditary sideroblastic anemia. This patient was treated with 200mg of pyridoxine per day during entire pregnancy period and further more, 4mg of oral folate per day was supplemented because concomitant folate deficiency is frequent in case of erythroid hyperplasia. Intermittently, the transfusions of packed red blood cells were required to maintain the hemoglobin level in the 9 to 10gm/dl range. We have experienced healthy maternal and perinatal outcome.

Rate of Synthesis and Degradation of Lysozyme Protein by Retinoic Acid in Normal Human Airway Epithelial Cells / 대한이비인후과학회지

BACKGROUND AND OBJECTIVES: We considered two possible mechanisms that might be responsible for the increased accumulation of lysozyme in retinoic acid (RA)-deficient cultures, either increased lysozyme synthesis or decreased lysozyme degradation based on our previous data. This study was to determine whether the synthesis and decay rate of intracellular lysozyme in RA-sufficient cultures are different from those in RA-deficient cultures. MATERIALS AND METHOD: Passage-2 normal human airway epithelial cells were used. For synthesis rate of lysozyme, day 10 RA-deficient and RA-sufficient cultures, incubated over 6 hour period with 35S-methionine-cysteine and cell lysates, were collected. For decay rate, day 10 cultures grown in the presence or absence of RA were labeled with 35S-methionine-cysteine for 4 hours and the labeling media were then removed. Cell extracts were collected over 8 hours. Newly synthesized or labeled lysozyme was immunoprecipitated with anti-lysozyme antibody and separated by SDS-PAGE. RESULTS: Lysozyme synthesis rate in RA-sufficient cultures was higher than in RA-deficient cultures. In the RA-deficient cultures, the levels of newly synthesized lysozyme barely changed over the 8 hour post-labeling period. In contrast, in the RA-sufficient cultures, radiolabeled lysozyme levels decreased rapidly during the 8 hour post-labeling period, with a half-life of approximately 6 hours. CONCLUSION: Discrepancy in mRNA and protein of lysozyme in RA-deficient cultures is due to the increased stability of lysozyme protein in RA-deficient cultures.

The Study of Bilateral Venign Vocal Fold Lesions / 대한이비인후과학회지

BACKGROUND AND OBJECTIVES: Benign vocal fold lesions are a common cause of voice dysfunction. Successful treatment of these diseases is primarily accomplished through voice therapy and surgical treatment. But many clinicians are faced with cases where problems persist in spite of treatment. The one cause of treatment failure in benign vocal fold lesions may be the bilateral lesions each vocal fold has different lesion. Authors studied to evaluate the possibility of persisted voice dysfunction in bilateral benign vocal fold lesions. MATERIALS AND METHODS: Strobovideolaryngoscopy findings of 128 patients with bilateral benign vocal fold lesions were reviewed. We evaluate to see if lesions in each vocal fold of one patient were the same or not. The treatment methods for each lesion were classified. We compare the treatment methods for each lesion with those already performed on the patients. RESULTS: In cases with nodule in one vocal fold, we observed 8 edema, 2 epidermoid cyst in the opposite vocal fold. In cases with reinke's edema on both vocal fold, we observed combined lesion, such as 1 epidermoid cyst, 1 hyperkeratosis. In cases with sulcus vocalis on both vocal fold, we observed combined lesion, such as 3 nodules, 4 polyps, 6 edema. We observed 2 cases with epidermoid cyst in one side and edema in opposite vocal fold, 5 cases with bilateral vocal nodule and combined varices in one side, 2 cases with bilateral laryngeal edema and combined hyperkeratosis in one side. CONCLUSION: Bilateral benign vocal fold lesions sometimes have more than 2 laryngeal diseases for which the treatment modality is different. Clinician should know the lesion precisely in each vocal fold, and treatment plan should be also made in according to the lesion in each vocal fold.

Effect of C1 esterase inhibitor on the cardiac dysfunction following ischemia and reperfusion in the isolated perfused rat heart

Complement-mediated neutrophil activation has been hypothesized to be an important mechanism of reperfusion injury. It has been proposed that C1 esterase inhibitor (C1 INH) may prevent the complement-dependent activation of polymorphonuclear leukocytes (PMNs) that occurs within postischemic myocardium. Therefore, The effect of C1 INH was examined in neutrophil dependent isolated perfused rat heart model of ischemia (I) (20 min) and reperfusion (R) (45 min). Administration of C1 INH (5 mg/Kg) to I/R hearts in the presence of PMNs (100 X 106) and homologous plasma improved coronary flow and preserved cardiac contractile function (p<0.001) in comparison to those I/R hearts receiving only vehicle. In addition, C1 INH significantly (p<0.001) reduced PMN accumulation in the ischemic myocardium as evidenced by an attenuation in myeloperoxidase activity. These findings demonstrate the C1 INH is a potent and effective cardioprotective agent inhibits leukocyte-endothelial interaction and preserves cardiac contractile function and coronary perfusion following myocardial ischemia and reperfusion.

Supernumerary Tooth in Nasal Cavity: Report of 1 Case / 대한이비인후과학회지

Supernumerary tooth, named mesodens, occur between the maxillary central incisors are generally found in pairs, although it is sometimes found singly. An inverted mesiodens may move toward the nasal cavity and erupt in the floor of the nose. Approximately 90% of all supernumerary tooth usually appear in the area of the maxilla, where they disrupt the position and eruption of normal teeth. A supernumerary tooth may closely resemble the teeth of the group to which it belongs, i.e., molars, premolars or anterior teeth.

Horizontal and Vertical Fusional Amplitudes in Normal Eyes

Fusional amplitudes can be measured using various clinical techniques and targets. But the vergence ranges are different according to the used instruments and the environmental conditions. Currently, measurement with the prism is usually llsed but this method have wide vardabele ranges by the used targets and environmental settings. The authors measured the vertical and horizontal fusional amplitudes of 135 normal Korean men with rotary prism in a well-lit office and compared the group using dim light targer with the group using small letter target. In the group using dim light target, true far convergence value was 14.67 +/- 6.24 delta, true far divergence was 6.64 +/- 3.48 delta, true near convergence was 24.96 +/- 7. 33 delta, true near divergence was 11.05 +/- 5.13delta, far vertical vergence was 2.93 +/-0.95 delta, and near vertical vergence was 3.40 +/- 1.15 delta, There was no statistical differences among are groups(p>0.05), and between the groups using small letter target and dim light target in true near and far convergence amplitudes (p>0.05). This study shows that the method using dim light target is simple and valuable method in measuring the fusional vergences.

A Case of Ota Nevus Associated with Altitudinal Field Defect

The nevus of Ota is a benign nevus characterized by the deposition of pigment in an area of distribution of the first and second branches of the trigeminal nerve. In general it rarely causes ophthalmological problems. We experienced a 23-year-old male patient who complained sudden visual loss in the left eye with the characteristics of the nevus of Ota. On examination we found the altitudinal field defect which we believe is an unusual finding of the nevus of Ota.