ABSTRACT
Introduction@#Ciprofloxacin is a broad-spectrum antibiotic that acts against a number of bacterial infections. The study was carried out to examine the in vitro quality control tests for five leading brands of ciprofloxacin hydrochloride 500 mg tablet formulation, registered in Mongolia. The quality control parameters of five different brands of ciprofloxacin hydrochloride 500 mg tablets were determined weight variation, friability, hardness, and disintegration, dissolution and assay tests. In addition, 0 and first order kinetic models were applied for each sample.@*Method@#All the tablets were evaluated for conformity with British Pharmacopoeia (BP) and Mongolian Pharmacopoeia-National Formulary (MP-NF) standards.@*Results@#Among five brands of tablets Brand C had lower mean weight variation of 0.8% and Brand A had highest mean weight variation of 3.42%. For friability test Brand B had the lowest mean friability (0.57) and Brand A had highest mean friability (1.51). The percentages of the drug content of five brands of ciprofloxacin tablet were obtained in the following sequence: Brand E (98.4 %) < Brand C (100.3%) < Brand D (115.1%) < Brand A (138.5%) < Brand B (183.8%). E and C brands met the BP and MP-NF specifications for assay@*Conclusion@#The present study revealed that Brand A, B and D the leading brands of this tablet not met the quality control parameters as per pharmacopoeia specifications expect dissolution test for some brands (Brand A, Brand B).